UGT1A6 Activators
UGT1A6 Activators belong to a class of chemical compounds that possess the unique ability to interact with and modulate the activity of the UDP-glucuronosyltransferase 1A6 enzyme (UGT1A6). UGT1A6 is a member of the UDP-glucuronosyltransferase (UGT) enzyme superfamily, responsible for a crucial phase II detoxification process in the liver and other tissues. These enzymes play a vital role in the metabolism and elimination of a wide range of endogenous compounds, drugs, and xenobiotics by catalyzing the transfer of glucuronic acid from UDP-glucuronic acid to specific functional groups on substrates. UGT1A6 activators are compounds that can influence the expression, stability, or enzymatic activity of UGT1A6, impacting the metabolic clearance and detoxification of various substances within the body.
The mechanism of action of UGT1A6 activators typically involves their capacity to modulate the transcriptional regulation of the UGT1A6 gene, post-translational modifications of UGT1A6, or the interaction of UGT1A6 with co-factors and substrates. UGT1A6 is subject to transcriptional regulation by various factors, and activators may influence the binding of these factors to UGT1A6 promoter regions, thereby affecting the expression of the enzyme. Additionally, activators can impact the stability or activity of UGT1A6 by modifying its phosphorylation, acetylation, or other post-translational modifications. Moreover, they may affect the recruitment of UGT1A6 to specific cellular compartments or its interaction with co-factors and substrates, which can further modulate its enzymatic function in detoxification processes. Understanding the properties and effects of UGT1A6 activators is crucial in the field of drug metabolism and xenobiotic detoxification, as it provides insights into the molecular mechanisms that govern the metabolism and elimination of foreign compounds and endogenous substances. It contributes to our understanding of how specific compounds can influence the body's ability to detoxify and eliminate harmful substances, ultimately impacting overall health and well-being.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clofibric acid | 882-09-7 | sc-203000 sc-203000A | 10 g 50 g | $24.00 $40.00 | 1 | |
As a peroxisome proliferator-activated receptor (PPAR) agonist, clofibric acid can indirectly increase UGT1A6 activity by modulating the expression of genes involved in glucuronidation. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz activates UGT1A6 by inducing its expression through the Nrf2 pathway, which is involved in the cellular response to oxidative stress and the regulation of detoxifying enzymes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate UGT1A6 by influencing its gene expression, likely through interactions with signaling pathways like AMPK, which are implicated in metabolic regulation. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
This polyphenol activates UGT1A6 by modulating gene expression, possibly through antioxidant response elements (AREs) in the UGT1A6 gene promoter. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a dietary flavonoid, enhances UGT1A6 activity by affecting its gene expression, likely through interaction with multiple signaling pathways including Nrf2. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin activates UGT1A6 by modulating gene expression. Its mechanism may involve the activation of PPAR receptors or other nuclear factors influencing UGT1A6 transcription. | ||||||
Tangeretin | 481-53-8 | sc-202826 | 10 mg | $422.00 | ||
This flavonoid found in citrus peels activates UGT1A6 by inducing its expression. The exact mechanism may involve nuclear receptor modulation or direct interaction with gene promoter elements. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, a compound in cruciferous vegetables, activates UGT1A6 by inducing gene expression through Nrf2-mediated pathways, enhancing the detoxification process. | ||||||