UFD1 Inhibitors
UFD1 inhibitors represent a class of chemical compounds that specifically target the UFD1 protein, a crucial component of the ubiquitin fusion degradation 1 (UFD1) complex. The UFD1 complex plays a pivotal role in the ubiquitin-proteasome system, which is responsible for the regulated degradation of cellular proteins. The ubiquitin-proteasome system serves as a quality control mechanism by identifying and disposing of damaged or unwanted proteins, thereby maintaining cellular homeostasis. UFD1, along with its interacting partner NPL4, forms a heterodimeric complex that facilitates the recognition and delivery of ubiquitinated substrates to the proteasome for degradation.
UFD1, by specific chemical agents, disrupts the normal functioning of the UFD1 complex, leading to a perturbation in the ubiquitin-proteasome system. This interference may result in the accumulation of ubiquitinated proteins within the cell, compromising its ability to maintain protein quality control. The consequences of UFD1 inhibition are intricate and involve intricate molecular pathways related to protein degradation and cellular regulation. Researchers are actively investigating the potential implications of UFD1 inhibitors in understanding fundamental cellular processes and exploring the broader ramifications of modulating the ubiquitin-proteasome system.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can block the degradation process of ubiquitinated proteins, potentially influencing UFD1 associated pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Another proteasome inhibitor, can halt the ubiquitin-proteasome pathway where UFD1 plays a role in protein degradation. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
A proteasome inhibitor that can interfere with the ubiquitin-proteasome system, thereby indirectly affecting UFD1 function. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
A compound known to inhibit endoplasmic reticulum associated degradation (ERAD), a process where UFD1 has a crucial role. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
An inhibitor of NEDD8-activating enzyme (NAE), can disrupt the neddylation process which is essential for ubiquitin-proteasome system. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Inhibitor of the proteasome, can interfere with protein degradation where UFD1 is involved. | ||||||
ONX 0914 | 960374-59-8 | sc-477437 | 5 mg | $245.00 | ||
Selective inhibitor of the immunoproteasome subunits LMP2 and LMP7, can indirectly affect UFD1 function by altering protein degradation pathways. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
A broad-spectrum deubiquitinating enzyme (DUB) inhibitor, can indirectly affect UFD1 by inhibiting protein deubiquitination. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
Inhibits proteasome-associated deubiquitinating enzyme USP14, can indirectly influence UFD1 through the ubiquitin-proteasome system. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Natural compound that can inhibit proteasome activity, indirectly influencing UFD1 related pathways. | ||||||