UBAP1L Activators
UBAP1L Activators are a diverse set of chemical compounds that indirectly augment the functional activity of UBAP1L through the modulation of various signaling pathways. Compounds like Forskolin and Epigallocatechin gallate (EGCG) work by activating adenylate cyclase to increase cAMP levels or inhibiting certain kinases, respectively. These actions can lead to the activation of pathways that involve PKA or reduce competitive kinase signaling, which may result in an environment where UBAP1L's role in cellular processes, such as endocytic trafficking, is enhanced. Similarly, bioactive lipids like Sphingosine-1-phosphate (S1P) and calcium ionophores such as Ionomycin and A23187 indirectly influence UBAP1L's activity by engaging S1P receptors or elevating intracellular calcium levels, thereby affecting cytoskeletal rearrangements and protein sorting, where UBAP1L may play crucial roles. Phorbol 12-myristate 13-acetate (PMA) activates PKC, leading to a downstream effect on cell signaling that could amplify UBAP1L-mediated endocytic pathways, while LY294002 and U0126 target the PI3K/Akt and MAPK/ERK pathways, potentially allowing for greater UBAP1L activity by decreasing inhibitory influences within those pathways.
The activity of UBAP1L is further influenced by inhibitors like Staurosporine, which, despite its broad-spectrum kinase inhibition, may inadvertently favor UBAP1L's involvement by lifting the inhibition of kinases that negatively regulate UBAP1L-associated signaling. The calmodulin antagonist W-7 and the selective PKC inhibitor Gö6976 also play a role in modulating signaling networks that could lead to the enhancement of UBAP1L's function by disrupting calcium-calmodulin-dependent processes or conventional PKCs, respectively. These compounds collectively contribute to a signaling milieu that can indirectly enhance the functional activity of UBAP1L, by either promoting signaling events that require UBAP1L-mediated processes or by altering the cellular context to necessitate UBAP1L's roles in processes such as ubiquitin-dependent signaling, endosomal sorting, and vesicle trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylate cyclase, resulting in increased levels of cyclic AMP (cAMP) within cells. Elevated cAMP levels may indirectly enhance the functional activity of UBAP1L by promoting cAMP-dependent protein kinase (PKA) signaling, which can phosphorylate substrates that potentially interact with or regulate UBAP1L's activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates S1P receptors and modulates various signaling pathways including those that regulate cytoskeletal rearrangements and cellular adhesion. Activation of these pathways can indirectly influence UBAP1L function by altering the cellular context in which UBAP1L operates, possibly affecting its interactions with other proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which plays a role in numerous signaling pathways including those involved in cell proliferation, differentiation, and migration. By activating PKC, PMA may indirectly increase UBAP1L activity by promoting signaling events that require UBAP1L-mediated processes, such as endocytic trafficking or ubiquitin-dependent signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby potentially influencing calcium-dependent signaling pathways. As cellular processes such as vesicle trafficking and protein sorting are affected by calcium signals, ionomycin could indirectly enhance UBAP1L activity by creating a cellular environment that necessitates its function in endosomal sorting. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase inhibitory activity. By inhibiting certain kinases, EGCG may reduce competitive signaling and indirectly increase UBAP1L activity by allowing pathways where UBAP1L is a functional player to be more prominent, particularly in the context of protein trafficking and turnover where UBAP1L's role could be critical. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, similar to ionomycin, and can thereby indirectly enhance UBAP1L activity by modulating calcium-dependent signaling pathways that influence UBAP1L's function in endocytic pathways and protein sorting mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K), which can modulate PI3K/Akt signaling. By inhibiting this pathway, LY294002 may indirectly enhance UBAP1L's role in endocytic trafficking and signaling by reducing inhibitory signaling and allowing UBAP1L-mediated pathways to become more active. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting MEK, U0126 could lead to the increased activity of UBAP1L by altering the cellular signaling dynamics, potentially enhancing UBAP1L's involvement in pathways that are regulated by MAPK/ERK signaling, such as endosomal sorting. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that may, paradoxically, enhance UBAP1L function by inhibiting kinases that negatively regulate pathways in which UBAP1L is involved. By lifting such inhibitions, staurosporine could create a signaling environment that indirectly increases the demand for UBAP1L's role in the endocytic pathway or ubiquitin signaling. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 is a calmodulin antagonist that interferes with calcium-calmodulin-dependent processes. By disrupting these processes, W-7 could indirectly enhance UBAP1L activity by altering signaling pathways that rely on calmodulin, thus potentially shifting the balance of intracellular signaling towards pathways where UBAP1L has a functional role. | ||||||