Tyro3 Activators
The term Tyro3 Activators refers to a class of chemical compounds that specifically target and activate the Tyro3 receptor, which is a member of the TAM (Tyro3, Axl, and Mer) family of receptor tyrosine kinases. These receptors play a crucial role in various physiological processes, particularly in regulating immune responses, tissue homeostasis, and cell survival. Tyro3, in particular, is known for its involvement in mediating cell signaling pathways that control phagocytosis, immune cell function, and tissue repair. Tyro3 activators are designed to modulate the activity of this receptor, either by enhancing its signaling or by stabilizing its active conformation, thereby influencing downstream cellular processes.
Chemically, Tyro3 activators can take various forms, including small molecules or biologics like antibodies. These compounds typically interact with specific binding sites on the Tyro3 receptor, triggering a conformational change that leads to the activation of its intrinsic kinase activity. This activation, in turn, initiates a cascade of intracellular signaling events, ultimately affecting cellular responses. Understanding the mechanisms and specific binding interactions of Tyro3 activators is of great interest in the field of molecular pharmacology and cell biology, as it sheds light on the intricate regulatory networks governing immune function and tissue maintenance. Researchers are actively exploring the potential of Tyro3 activators to modulate these pathways for various applications such as in the study of immune system dynamics, tissue regeneration, and disease mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 is known to modulate the immune system, and its metabolites may influence the expression of various genes, potentially including Tyro3, by binding to the vitamin D receptor which can then interact with specific DNA sequences. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a role in cell growth and differentiation. It may enhance Tyro3 expression through binding to retinoic acid receptors, which can interact with the Tyro3 promoter region to modulate its transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol, a form of estrogen, may influence Tyro3 expression as estrogens have been found to modulate the expression of various genes, possibly through estrogen receptor-mediated mechanisms that affect transcriptional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can influence the expression of various genes, potentially including Tyro3, through insulin receptor signaling pathways, which may lead to changes in transcriptional activity and protein expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, may affect Tyro3 expression through glucocorticoid receptor-mediated pathways, impacting gene transcription in cells where Tyro3 is expressed. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone is known to modulate gene expression through its receptor, which may include influencing the transcription of Tyro3 in certain tissues. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride has been shown to influence various cellular processes and gene expressions, possibly including Tyro3, through pathways such as the Wnt/β-catenin signaling pathway. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, can modulate gene expression and has been shown to affect histone deacetylases, potentially influencing Tyro3 expression through epigenetic modifications. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, is known to modulate various signaling pathways and gene expressions, potentially including Tyro3, through mechanisms that may involve its antioxidant properties and interactions with signaling proteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a bioactive compound from turmeric, can modulate various signaling pathways and gene expressions. Its potential effect on Tyro3 expression may be mediated through its anti-inflammatory and antioxidant properties. | ||||||