Type II 4-phosphatase Inhibitors
Type II 4-phosphatase inhibitors are chemical compounds that specifically target and inhibit the activity of the enzyme type II inositol polyphosphate 4-phosphatase (INPP4B). This enzyme is responsible for dephosphorylating the D-4 position of the inositol ring in phosphoinositides, particularly phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). Phosphoinositides play crucial roles in cellular signaling pathways, especially those involved in membrane trafficking, cytoskeletal organization, and cell growth. By removing the phosphate group from PI(3,4)P2, type II 4-phosphatase regulates the levels of specific signaling lipids, influencing downstream cellular processes. The precise regulation of these lipids is essential for maintaining cellular functions such as signal transduction and membrane dynamics.
Inhibitors of type II 4-phosphatase act by blocking the enzyme's catalytic activity, preventing it from dephosphorylating PI(3,4)P2 and related phosphoinositides. This leads to an accumulation of these signaling molecules, which can affect various pathways reliant on phosphoinositide signaling, including those that control membrane identity and trafficking. The inhibition of type II 4-phosphatase offers a valuable tool for researchers to investigate the regulatory roles of phosphoinositides in cellular signaling networks. By modulating the enzyme's activity, these inhibitors enable scientists to study how altered phosphoinositide metabolism impacts processes such as vesicular trafficking, cytoskeletal dynamics, and cell signaling. Understanding the role of type II 4-phosphatase through the use of these inhibitors helps to reveal the broader implications of phosphoinositide regulation in maintaining cellular homeostasis and organization.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
A potent inhibitor of protein kinase C (PKC) that indirectly modulates Type II 4-phosphatase. PKC, a downstream effector in various signaling cascades, phosphorylates and activates Type II 4-phosphatase, enhancing its activity. Inhibition of PKC by Bisindolylmaleimide I disrupts this activation, leading to reduced Type II 4-phosphatase activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An irreversible inhibitor of phosphoinositide 3-kinase (PI3K) that indirectly influences Type II 4-phosphatase. PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a key regulator of Type II 4-phosphatase activation. Wortmannin inhibits PI3K, reducing PIP3 levels and attenuating the stimulatory effect on Type II 4-phosphatase, thereby indirectly inhibiting its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, indirectly affecting Type II 4-phosphatase. Okadaic Acid disrupts the balance of phosphorylation events by inhibiting PP1 and PP2A, leading to aberrant phosphorylation of Type II 4-phosphatase and modulation of its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that indirectly influences Type II 4-phosphatase. mTOR is involved in various cellular processes, including the regulation of Type II 4-phosphatase. Rapamycin inhibits mTOR, disrupting the signaling pathway and indirectly affecting Type II 4-phosphatase activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, indirectly affecting Type II 4-phosphatase. Calyculin A disrupts the equilibrium of phosphorylation events by inhibiting PP1 and PP2A, leading to altered phosphorylation patterns of Type II 4-phosphatase and modulation of its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that indirectly influences Type II 4-phosphatase. PI3K generates PIP3, a known regulator of Type II 4-phosphatase activation. LY294002 inhibits PI3K, reducing PIP3 levels and attenuating the stimulatory effect on Type II 4-phosphatase, indirectly inhibiting its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that indirectly modulates Type II 4-phosphatase. p38 MAPK is involved in various signaling pathways, including those regulating Type II 4-phosphatase. SB203580 inhibits p38 MAPK, disrupting the signaling cascade and indirectly affecting Type II 4-phosphatase activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum protein kinase inhibitor that indirectly modulates Type II 4-phosphatase. By inhibiting multiple kinases, including those in pathways regulating Type II 4-phosphatase, Staurosporine disrupts the signaling cascades and indirectly influences the activity of Type II 4-phosphatase. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK1 inhibitor that indirectly influences Type II 4-phosphatase. MEK1 is an upstream regulator in the MAPK pathway, which modulates Type II 4-phosphatase activity. PD98059 inhibits MEK1, disrupting the MAPK pathway and indirectly inhibiting Type II 4-phosphatase. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An adenylate cyclase activator that indirectly influences Type II 4-phosphatase. Forskolin elevates cAMP levels, activating downstream signaling cascades that impact Type II 4-phosphatase. The increased cAMP levels can modulate Type II 4-phosphatase activity indirectly by influencing its regulatory pathways. | ||||||