Type II 4-phosphatase Antibody (3F2): sc-293234

Type II 4-phosphatase Antibody (3F2) is a mouse monoclonal IgG2b antibody that detects Type II 4-phosphatase of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Type II 4-phosphatase antibody (3F2) is available as a non-conjugated format. Type II 4-phosphatase plays a crucial role in cellular signaling by selectively dephosphorylating phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate, generating second messengers that mediate various physiological responses to extracellular signals. Type II 4-phosphatase is predominantly located in the cytoplasm and regulates intracellular calcium levels, which is vital for numerous cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. Type II 4-phosphatase appears in various tissues, such as human platelets, rat brain, heart, skeletal muscle, and spleen, underscoring its importance in maintaining cellular homeostasis and responding to external stimuli. Both type I and type II 4-phosphatases are alternatively spliced into two isoforms, α and β, which share a conserved motif containing the active site consensus sequence C-X5-R, highlighting their evolutionary significance and functional conservation. Type II 4-phosphatase acts as a signal-terminating enzyme, emphasizing its role in fine-tuning cellular responses and making it a valuable target for research in signal transduction pathways.

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Type II 4-phosphatase Antibody (3F2) References:

1. The role of phosphatases in inositol signaling reactions.  |  Majerus, PW., et al. 1999. J Biol Chem. 274: 10669-72. PMID: 10196133
2. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.  |  Gewinner, C., et al. 2009. Cancer Cell. 16: 115-25. PMID: 19647222
3. The isolation and characterization of inositol polyphosphate 4-phosphatase.  |  Bansal, VS., et al. 1990. J Biol Chem. 265: 1806-11. PMID: 2153145
4. Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells.  |  Kim, JS., et al. 2012. Cancer Biol Ther. 13: 1307-18. PMID: 22895072
5. MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells.  |  Chen, H., et al. 2017. Tumour Biol. 39: 1010428317695941. PMID: 28345464
6. Down-regulation of Inositol Polyphosphate 4-Phosphatase Type II Expression in Colorectal Carcinoma.  |  Sung, JY., et al. 2017. Anticancer Res. 37: 5525-5531. PMID: 28982866
7. Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas.  |  Zhang, B., et al. 2018. Cell Adh Migr. 12: 548-563. PMID: 29952716
8. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.  |  Zhang, M., et al. 2019. Oncogene. 38: 1121-1135. PMID: 30228349
9. Expression of inositol polyphosphate 4-phosphatase type II and the prognosis of oral squamous cell carcinoma.  |  Yang, QC., et al. 2020. Eur J Oral Sci. 128: 37-45. PMID: 32027770
10. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.  |  Norris, FA., et al. 1995. J Biol Chem. 270: 16128-33. PMID: 7608176
11. Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets.  |  Norris, FA., et al. 1997. J Biol Chem. 272: 10987-9. PMID: 9110986
12. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.  |  Norris, FA., et al. 1997. J Biol Chem. 272: 23859-64. PMID: 9295334

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Type II 4-phosphatase Antibody (3F2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Type II 4-phosphatase Antibody (3F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Type II 4-phosphatase Antibody (3F2) Specifications

Alternate Product Name: Type II 4-phosphatase

Product Clone Name: 3F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b lambda light chain

Amino Acids: 1-53

Epitope Target: Type II 4-phosphatase

Epitope Species: human

Product Reactivity/Detection: Type II 4-phosphatase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Type II 4-phosphatase Antibody (3F2): N/A