TWISTNB Inhibitors
TWISTNB inhibitors constitute a category of chemical agents designed to selectively interact with the biological target known as TWISTNB, a transcription factor involved in various cellular processes. TWISTNB, or Twist Neighbor, is a protein that may play a crucial role in the regulation of gene expression, influencing cellular functions and mechanisms at a molecular level. Inhibitors in this class are characterized by their ability to bind to the TWISTNB protein, thereby modulating its activity. The design of these compounds is often centered around the specific structural features of the TWISTNB protein, which typically includes recognizing and fitting into the protein's active site or other relevant binding domains.
The development of TWISTNB inhibitors involves intricate chemical engineering and a deep understanding of protein-ligand interactions. The chemical structure of such inhibitors is generally optimized through various iterations of synthesis and testing to ensure high specificity and potency. This specificity is crucial to minimize off-target effects and to ensure that the interaction with the TWISTNB protein is as efficient as possible. Molecular docking studies, structure-activity relationship (SAR) analyses, and computational modeling are among the tools used by chemists to predict how these inhibitors will interact with their target and to refine their structures accordingly. The ultimate goal in the design of TWISTNB inhibitors is to achieve a high degree of precision in targeting, with the compounds exhibiting a strong affinity for TWISTNB and a high level of selectivity to avoid interaction with other proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated protein kinase), which indirectly affects the actin cytoskeleton organization. Inhibition of ROCK can lead to reduced cell motility and altered cell shape, which can indirectly downregulate TWISTNB expression, as TWISTNB is involved in processes requiring cytoskeletal changes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K (phosphoinositide 3-kinases). By inhibiting PI3K, it can halt the downstream AKT signaling pathway, resulting in decreased cell survival and proliferation signals that can negatively impact TWISTNB function, which is implicated in cell proliferation and survival. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is upstream of the ERK pathway. By inhibiting MEK, it prevents the activation of ERK, potentially leading to reduced transcriptional activity of genes like TWISTNB that are associated with cell proliferation and migration. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 specifically inhibits TGF-β type I receptor ALK5, which leads to decreased activation of SMAD proteins. Since TGF-β signaling can induce the expression of proteins like TWISTNB, involved in epithelial-to-mesenchymal transition (EMT), the inhibition of this pathway can result in downregulation of TWISTNB. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of misfolded proteins and subsequent cellular stress. This can downregulate protein synthesis, including the synthesis of TWISTNB, as the cell attempts to mitigate stress. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K like LY294002, and it similarly disrupts the AKT pathway. This can diminish the transcription and activity of proteins associated with cell survival and proliferation, such as TWISTNB, by reducing the signals necessary for their expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, and by impeding the activation of the MAPK/ERK pathway, it can decrease the transcription of genes involved in cell proliferation and differentiation, including TWISTNB. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), which is part of the MAPK family and involved in cell stress and apoptosis. By inhibiting JNK, it can alter transcriptional regulation of genes such as TWISTNB, which are involved in cellular responses to stress. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a gamma-secretase inhibitor that prevents the cleavage of proteins like Notch, thus inhibiting the Notch signaling pathway. As Notch can regulate genes involved in cell differentiation and proliferation, inhibiting this pathway can result in a decrease in TWISTNB levels. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a selective inhibitor of c-Raf kinase, which is part of the MAPK/ERK pathway. Its inhibition can lead to decreased signaling necessary for the transcription and function of proteins involved in cell migration and proliferation, such as TWISTNB. | ||||||