Date published: 2026-5-5

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TTF Inhibitors

TTF inhibitors, or thiophene-fused tetrathiafulvalene inhibitors, represent a distinctive chemical class characterized by their unique molecular structure and functional attributes. TTF itself is a sulfur-containing organic molecule that gained prominence for its electron-donating properties, and these inhibitors exhibit a pronounced impact on certain biological processes. The core of TTF inhibitors consists of a tetrathiafulvalene moiety, a fused thiophene ring system that imparts the compound with its distinctive electronic characteristics. This structural motif is central to the compound's ability to interact with specific molecular targets.

TTF inhibitors is driven by the desire to modulate biological pathways or processes by leveraging the unique electronic properties of the tetrathiafulvalene core. Researchers have explored the potential of TTF inhibitors in various contexts, aiming to exploit their ability to interact with specific proteins or enzymes. The underlying rationale involves the intricate interplay between the electron-rich TTF moiety and the target molecule, leading to potential alterations in the target's activity. This class of inhibitors holds promise in the realm of chemical biology and molecular pharmacology, where the focus is on understanding and manipulating biological systems at the molecular level. The distinctive chemical structure of TTF inhibitors underscores their potential as tools for probing and unraveling complex biochemical pathways, paving the way for deeper insights into the fundamental processes that govern cellular function.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Inhibits PI3K, a kinase involved in a pathway that can regulate TTF1 activity by affecting transcription factor phosphorylation and localization.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

Another PI3K inhibitor, which can alter TTF1 activity indirectly through the PI3K/Akt pathway.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

Inhibits MEK, which is part of the MAPK/ERK pathway, a signaling cascade that can influence TTF1 activity through downstream effects on gene expression.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Inhibits JNK, which can modulate TTF1-related pathways and activity by altering transcription factor dynamics within the cell.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

A p38 MAPK inhibitor, which can affect TTF1 function by impacting inflammatory response pathways that interact with TTF1-regulated genes.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Binds to mTOR, which is part of a pathway that can intersect with TTF1's regulatory roles, thus influencing its activity indirectly.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

A compound known to inhibit multiple transcription factors, potentially affecting TTF1 by changing the overall transcriptional environment in the cell.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

A compound that impacts various signaling pathways and may alter TTF1 activity by modifying the transcriptional network within cells.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

A compound that can influence the NRF2 pathway and thus indirectly modulate TTF1 activity through oxidative stress response pathways.

Chetomin

1403-36-7sc-202535
sc-202535A
1 mg
5 mg
$186.00
$674.00
10
(1)

Disrupts the function of hypoxia-inducible factors (HIFs), which could lead to alterations in TTF1 activity given the role of HIFs in gene regulation.