TTC36 Inhibitors
Chemical inhibitors of TTC36 can act through various cellular pathways to achieve inhibition of this specific protein's function. Staurosporine, a broad-spectrum kinase inhibitor, can prevent the phosphorylation of TTC36, assuming that its activation or function is contingent upon this post-translational modification. Similarly, wortmannin and LY294002, both phosphoinositide 3-kinases (PI3K) inhibitors, can interfere with the PI3K signaling that may be required for TTC36's functional conformation or localization within the cell. U0126 and PD98059 are both selective inhibitors of MEK, part of the MAPK/ERK pathway, which, if involved in the regulation of TTC36, can result in its functional inhibition by blocking this particular pathway. SB203580 and SP600125, targeting p38 MAPK and JNK respectively, can inhibit TTC36 if it is modulated by these MAPK signaling pathways.
Rapamycin inhibits mTOR, and if TTC36 operates downstream of mTOR signaling, then the functional inhibition of TTC36 can be achieved through the inhibition of mTOR by rapamycin. PP2 and Lestaurtinib, both tyrosine kinase inhibitors, can impede TTC36 activity if it is regulated by tyrosine kinase signaling. GF109203X and Go6983, both inhibitors of protein kinase C (PKC), can suppress TTC36 function by inhibiting the PKC-mediated signaling that TTC36 might require for its activity. Each of these chemicals interacts with specific signaling pathways or enzymes that are postulated to influence TTC36 activity, leading to the inhibition of TTC36 through a cascade of cellular events that start with the inhibition of upstream regulators or direct phosphorylation events.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor known to phosphorylate a wide range of kinases which TTC36 may rely on for activation or proper functioning. Inhibition of these kinases can lead to reduced TTC36 activity due to lack of phosphorylation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). If TTC36's activity is dependent on PI3K signaling for its functional conformation or localization, wortmannin can inhibit TTC36 by inhibiting PI3K. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 functions similarly to wortmannin by inhibiting PI3K. Inhibition of this kinase might prevent proper trafficking or regulation of TTC36, resulting in its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK, which is a part of the MAPK/ERK pathway. TTC36, if regulated by ERK signaling for its activity, can be functionally inhibited by U0126 by blocking this signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. If TTC36 activity is modulated by p38 MAPK, then SB203580 can inhibit this signaling pathway, leading to functional inhibition of TTC36. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK signaling pathways. If TTC36 relies on JNK signaling for its function, inhibition by SP600125 would result in decreased TTC36 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central protein in regulating cell growth and metabolism. Should TTC36 function be downstream of mTOR signaling, rapamycin would inhibit its function by inhibiting mTOR. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src-family tyrosine kinase inhibitor. If TTC36 is activated or regulated by Src kinase signaling, its function will be inhibited by PP2 through the inhibition of Src kinases. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a protein kinase C inhibitor. If TTC36 requires PKC-mediated signaling for its activity, inhibition by GF109203X will lead to functional inhibition of TTC36. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor, which, by inhibiting the ERK pathway, could potentially inhibit TTC36 if its activity is dependent on this signaling pathway. | ||||||