TTC36 Activators
Chemical activators of TTC36 can induce various cellular signaling pathways, leading to its activation through phosphorylation. Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which directly phosphorylates TTC36, altering its activity within cells. Forskolin, by elevating cyclic AMP (cAMP) levels, activates protein kinase A (PKA) that also targets TTC36 for phosphorylation. In a different mechanism, Ionomycin raises intracellular calcium levels, which then activate calmodulin-dependent kinases capable of phosphorylating TTC36, integrating it into calcium-dependent signaling events. Another pathway involves Okadaic Acid and Calyculin A, both of which inhibit protein phosphatases that normally remove phosphate groups from proteins like TTC36; their action results in the sustained phosphorylation and, consequently, the activation of TTC36.
Anisomycin engages stress-activated protein kinases, which may phosphorylate TTC36 as part of the cellular response to stressors. Similarly, Thapsigargin disrupts calcium storage within the endoplasmic reticulum, triggering signaling cascades that may include the activation of TTC36 as part of the unfolded protein response. Tumor Necrosis Factor Alpha (TNF-α) activates the NF-kB signaling pathway, which can lead to the modification and activation of a range of proteins, including TTC36, as part of the inflammatory response. Moreover, Epidermal Growth Factor (EGF) stimulates the MAPK/ERK pathway, leading to TTC36 phosphorylation during cell proliferation and differentiation processes. Hydrogen Peroxide, through the induction of oxidative stress, activates signaling pathways that result in the phosphorylation of TTC36 as a response to oxidative conditions. Camptothecin, which induces a DNA damage response, can activate kinases that target TTC36 as part of the cellular response to DNA damage. Lastly, 6-Benzylaminopurine, associated with cell division and growth, can activate signaling pathways leading to TTC36 phosphorylation, indicating its role in cellular growth processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate activates protein kinase C (PKC), which in turn can phosphorylate TTC36, leading to its activation. PKC is a signaling molecule that directly phosphorylates target proteins, thereby modulating their function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which activates calmodulin-dependent kinases. These kinases may phosphorylate TTC36, leading to its activation as part of calcium signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases, which normally dephosphorylate proteins like TTC36. Inhibition of these phosphatases can result in the sustained activation of TTC36 by maintaining its phosphorylated state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, similar to Okadaic Acid, inhibits protein phosphatases leading to the accumulation of phosphorylated proteins. This inhibition can keep TTC36 in an activated state due to reduced dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases which are known to phosphorylate a variety of substrates, potentially including TTC36, thereby leading to its activation as part of cellular stress response pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium storage in the endoplasmic reticulum and activates signaling pathways that can lead to the phosphorylation and activation of TTC36 as part of the unfolded protein response. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide induces oxidative stress which activates signaling pathways that could lead to the phosphorylation and activation of TTC36 as part of the oxidative stress response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin induces DNA damage responses which activate kinases that can phosphorylate TTC36, leading to its activation as part of the DNA damage response pathway. | ||||||
6-Benzylaminopurine | 1214-39-7 | sc-202428 sc-202428A | 1 g 5 g | $20.00 $52.00 | ||
6-Benzylaminopurine activates signaling pathways that can lead to the phosphorylation and activation of TTC36, as cytokinins play a role in cell division and growth, which often involves the activation of various signaling proteins. | ||||||