Date published: 2026-5-30

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TSPY2 Inhibitors

The chemical class identified as TSPY2 Inhibitors constitutes a category of compounds designed to selectively target the molecular entity TSPY2. TSPY2, or Testis-Specific Protein Y-Encoded 2, belongs to the TSPY gene family predominantly expressed in the testis. While TSPY2 shares homology with the prototypical TSPY gene, its specific functional roles and interactions remain subjects of active investigation within the fields of reproductive biology and molecular genetics. Inhibitors within the TSPY2 Inhibitors class are intricately engineered molecules with the primary goal of modulating the activity or function of TSPY2, thereby inducing an inhibitory effect. Researchers engaged in this field utilize a multifaceted approach, integrating insights from structural biology, medicinal chemistry, and computational modeling to unravel the complex molecular interactions between the inhibitors and the target TSPY2.

Structurally, TSPY2 Inhibitors are characterized by specific molecular features designed to facilitate selective binding to TSPY2. This selectivity is crucial to minimize unintended effects on other cellular components, ensuring a focused impact on the intended molecular target. The development of inhibitors within this chemical class involves a comprehensive exploration of structure-activity relationships, optimization of pharmacokinetic properties, and a deep understanding of the molecular mechanisms associated with TSPY2. As researchers delve deeper into the functional aspects of TSPY2 Inhibitors, the knowledge generated contributes not only to deciphering the specific roles of Testis-Specific Protein Y-Encoded 2 but also to advancing our broader comprehension of reproductive biology and the intricate molecular events governing testicular functions. The exploration of TSPY2 Inhibitors stands as a significant avenue for expanding fundamental knowledge in molecular genetics and cellular physiology.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine inhibits DNA methyltransferase, potentially leading to demethylation and altered gene expression, which may affect TSPY2.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Trichostatin A, a histone deacetylase inhibitor, can change chromatin structure and thereby potentially downregulate TSPY2 expression.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Vorinostat alters gene expression by inhibiting histone deacetylase, which could in turn modulate TSPY2 expression levels.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

Mithramycin A binds to DNA and may inhibit transcription factor binding to gene promoters, potentially reducing TSPY2 expression.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

Decitabine is used to cause hypomethylation of DNA, which might influence the expression of TSPY2 indirectly.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid affects gene expression through nuclear receptors, which may have consequences for TSPY2 expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin is known to affect transcription factors and signaling pathways, potentially leading to changes in TSPY2 expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG has been linked to changes in DNA methylation and histone modification, possibly impacting TSPY2 expression.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein may modulate gene expression by affecting epigenetic modifications and could potentially influence TSPY2 expression.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Sirolimus inhibits mTOR signaling, affecting protein synthesis and cell proliferation, which might reduce TSPY2 expression.