TSLP Inhibitors
TSLP (Thymic Stromal Lymphopoietin) inhibitors are a class of chemical compounds that function by interfering with the activity of TSLP, a cytokine produced predominantly by epithelial cells in response to environmental stimuli, such as allergens and microbial products. TSLP plays a crucial role in the initiation and modulation of immune responses, particularly those associated with inflammation and allergic reactions. It exerts its effects by binding to a heterodimeric receptor complex composed of the TSLP receptor (TSLPR) and the interleukin-7 receptor alpha chain (IL-7Rα) on the surface of various immune cells, including dendritic cells, T cells, and mast cells. This interaction triggers a signaling cascade that leads to the activation of downstream pathways involved in the regulation of immune cell differentiation, proliferation, and cytokine production.
TSLP inhibitors typically work by blocking the binding of TSLP to its receptor complex, thereby preventing the activation of these downstream signaling pathways. This inhibition can be achieved through different mechanisms, such as directly targeting the TSLP cytokine itself, interfering with the receptor complex, or disrupting the receptor's ability to engage with TSLP. By blocking TSLP signaling, these inhibitors are valuable tools for studying the molecular mechanisms underlying immune responses, particularly those related to epithelial-immune cell communication and the regulation of inflammatory processes. Researchers utilize TSLP inhibitors to dissect the specific roles of TSLP in immune system function and to understand how this cytokine influences the behavior of various immune cell types. Through these studies, insights can be gained into the broader regulatory networks that govern immune homeostasis and the response to environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is a DNA intercalating agent that indirectly inhibits Matrin-3 by binding to DNA and disrupting transcription and RNA processing, consequently affecting Matrin-3's function in RNA metabolism. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase inhibitor that indirectly affects Matrin-3 by preventing proper DNA supercoiling and transcription, ultimately influencing Matrin-3's role in RNA metabolism. | ||||||
Aclacinomycin A | 57576-44-0 | sc-200160 | 5 mg | $132.00 | 10 | |
Aclacinomycin A is an anthracycline antibiotic that indirectly inhibits Matrin-3 by interfering with DNA replication and RNA synthesis, thereby impacting Matrin-3's involvement in RNA metabolism. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin is a topoisomerase inhibitor that indirectly affects Matrin-3 by preventing proper DNA supercoiling and transcription, ultimately influencing Matrin-3's role in RNA metabolism. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone is an anthracenedione derivative that indirectly inhibits Matrin-3 by interfering with DNA replication and RNA synthesis, thereby impacting Matrin-3's involvement in RNA metabolism. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is an antibiotic that indirectly modulates Matrin-3 by targeting RNA polymerase, affecting transcription processes and ultimately influencing Matrin-3's role in RNA metabolism. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a DNA-damaging agent that indirectly inhibits Matrin-3 by forming DNA adducts, disrupting transcription and RNA processing, consequently affecting Matrin-3's function in RNA metabolism. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil is an antimetabolite that indirectly affects Matrin-3 by disrupting nucleotide synthesis, leading to alterations in RNA metabolism processes in which Matrin-3 is involved. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
Thioguanine is an antimetabolite that indirectly inhibits Matrin-3 by interfering with purine nucleotide synthesis, leading to disruptions in RNA metabolism processes associated with Matrin-3. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase inhibitor that indirectly affects Matrin-3 by preventing proper DNA supercoiling and transcription, ultimately influencing Matrin-3's role in RNA metabolism. | ||||||