TRK-T3 Activators
TRK-T3" refers to a gene fusion involving the tropomyosin receptor kinase (TRK) family of genes, specifically the NTRK3 gene. This fusion results from a chromosomal rearrangement that combines part of the NTRK3 gene with another gene, leading to the creation of a chimeric or fusion protein. This fusion event is significant in the field of oncology, as it can drive the development and progression of certain types of cancer.
The NTRK3 gene itself encodes for a protein known as TRKC, a member of the TRK family of receptor tyrosine kinases. These proteins play critical roles in the development and function of the nervous system. They are involved in the regulation of cell survival, proliferation, and differentiation through their responsiveness to neurotrophin growth factors.In the context of cancer, the TRK-T3 fusion leads to the constitutive activation of the TRKC kinase domain. This constant activation can drive uncontrolled cell growth and survival, contributing to tumorigenesis. The presence of TRK-T3 and other NTRK fusions in tumors is of considerable interest because they represent a target for therapy. Drugs known as TRK inhibitors have been developed to specifically target cancers driven by NTRK gene fusions, including TRK-T3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride, a diuretic, can indirectly affect neuronal receptors and might influence TRK-T3 activity. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a, a kinase inhibitor, while primarily an inhibitor, can have complex effects on neurotrophic receptors and might indirectly affect TRK-T3. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Cyclic AMP, a secondary messenger, can modulate neuronal signaling pathways potentially influencing TRK-T3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, which may indirectly affect TRK-T3 activity in neurons. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, used in mood disorders, can affect neurotrophic signaling and potentially influence TRK-T3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, with its neuroprotective properties, might indirectly affect TRK-T3 through various signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, known for its neuroprotective effects, could indirectly influence TRK-T3 signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, might impact neuronal signaling pathways that include TRK-T3. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc, an essential mineral, can influence neuronal function and possibly affect TRK-T3 activity. | ||||||