TRIM64 Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 can inhibit the proteasomal degradation activities that TRIM64 may rely on for the regulation of protein turnover, leading to an accumulation of TRIM64's ubiquitinated substrate proteins and thus inhibiting TRIM64's function. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin irreversibly binds to the proteasomal subunits, inhibiting the proteasome's activity. Since TRIM64 is thought to be involved in tagging proteins for proteasomal degradation, inhibition of the proteasome would result in functional inhibition of TRIM64's role in this pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits the 26S proteasome, which is responsible for degrading ubiquitinated proteins. As TRIM64 is implicated in protein ubiquitination, its function is inhibited when proteasomal activity is blocked, preventing the degradation of its substrates. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin selectively inhibits the chymotrypsin-like activity of the proteasome. Inhibition of this activity can prevent the degradation of TRIM64's ubiquitinated targets, thereby inhibiting TRIM64's function in proteostasis. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine disrupts lysosomal function by raising the lysosomal pH, which could inhibit the lysosome-dependent degradation pathways that TRIM64 may utilize, leading to a functional inhibition of TRIM64's role in this pathway. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase (V-ATPase). If TRIM64 directs proteins to lysosomes for degradation, this inhibition would lead to functional inhibition of TRIM64's role in lysosomal degradation. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A inhibits the V-ATPase similar to Bafilomycin A1. Inhibition of V-ATPase can lead to dysfunction of lysosomal acidification, potentially inhibiting any lysosome-dependent pathways involving TRIM64. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E64 is an inhibitor of cysteine proteases. If TRIM64 requires the activation of cysteine proteases for its function or the function of its substrates, E64's inhibition of these enzymes would inhibit TRIM64's activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin inhibits serine and cysteine proteases, and its activity could hinder the proteolytic processing necessary for TRIM64's functional activity or the activity of its substrate proteins. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine inhibits autophagy by blocking autophagosome formation. If TRIM64 is involved in autophagic degradation, this would inhibit TRIM64's role in mediating this pathway. | ||||||