TRIM61 Activators
TRIM61 activators encompass a diverse set of chemical compounds that indirectly promote the functional activity of TRIM61 through intricate cellular signaling cascades. Forskolin, PMA, Ionomycin, 8-Br-cAMP, and Dibutyryl cAMP serve as potent agents that elevate intracellular second messengers like cAMP and calcium ions, which are crucial for the activation of protein kinases such as PKA and PKC. These kinases are responsible for the phosphorylation of target proteins, including TRIM61, thereby enhancing its activity. The action of isoproterenol similarly culminates in increased cAMP levels, leading to the activation of PKA and subsequent enhancement of TRIM61 function. On the other hand, the polyphenol EGCG, by inhibiting a broad spectrum of kinases, reduces phosphorylation competition, allowing kinases that specifically target TRIM61 to act more effectively.
Compounds like LY294002 and Wortmannin, by inhibiting PI3K, and U0126 and SB203580, by targeting MEK and p38 MAPK, respectively, shift the balance of intracellular signaling pathways. These shifts can lead to the activation of alternative pathways that enhance the functional activity of TRIM61. Thapsigargin's blockade of SERCA pumps raises intracellular calcium levels, thus activating calcium-dependent kinases that subsequently can lead to the phosphorylation and activation of TRIM61.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate TRIM61, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is involved in the phosphorylation of proteins like TRIM61, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate and activate TRIM61. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cAMP analog that activates PKA. PKA can then phosphorylate and enhance the activity of TRIM61. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is another cAMP analog that diffuses into cells and activates PKA, which subsequently can phosphorylate and activate TRIM61. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin blocks the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased intracellular calcium levels that can activate kinases phosphorylating TRIM61. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple kinases, potentially reducing competitive phosphorylation and allowing kinases that target TRIM61 to be more effective in activating it. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, thus leading to PKA activation and subsequent phosphorylation and activation of TRIM61. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to altered downstream signaling, potentially shifting the balance towards pathways that activate TRIM61. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can indirectly activate TRIM61 by affecting AKT signaling and other downstream pathways. | ||||||