TRIM49 Activators
Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can suppress various kinases within signaling pathways. If TRIM49 is regulated or stabilized by phosphorylation through certain kinases, staurosporine's broad-spectrum inhibition could indirectly reduce TRIM49's functional activity by preventing its phosphorylation-dependent stabilization. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin may indirectly increase TRIM49 by modulating cellular processes related to inflammation and immune response. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Given that TRIM49 is an E3 ubiquitin ligase, MG132 can lead to the accumulation of TRIM49's substrates, potentially causing feedback inhibition that decreases TRIM49's ligase activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that can cause the accumulation of proteins targeted for degradation. Similar to MG132, by preventing substrate degradation, TRIM49's activity could be indirectly inhibited due to the build-up of its substrates. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib may indirectly increase TRIM49 activation through its modulation of the JAK-STAT pathway and interferon-related signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor used to prevent the breakdown of proteins, including those ubiquitinated by TRIM49. This can lead to an accumulation of substrates and potential feedback inhibition of TRIM49's E3 ligase activity. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Similar to atorvastatin, simvastatin may indirectly activate TRIM49 through its effects on inflammation and immune processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An autophagy inhibitor that can increase cellular stress. By disrupting autophagic processes, chloroquine might lead to the accumulation of TRIM49 substrates, indirectly affecting TRIM49's activity through altered cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may indirectly activate TRIM49 by influencing immune and inflammatory responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can disrupt downstream AKT signaling. If TRIM49 activity is dependent on AKT-mediated signaling for its stability or localization, LY294002 could indirectly inhibit TRIM49's function by altering AKT activity. | ||||||