TRIM43A Inhibitors
TRIM43A inhibitors represent a class of chemical compounds specifically designed to interact with the TRIM43A protein, a member of the tripartite motif-containing (TRIM) protein family. TRIM proteins are characterized by a highly conserved tripartite motif, which includes a RING domain, one or two B-box domains, and a coiled-coil region. TRIM43A is known to be involved in various cellular processes, including ubiquitination, a process where proteins are tagged for degradation via the proteasome system. Inhibition of TRIM43A alters its normal function in regulating ubiquitination pathways, impacting the downstream signaling processes that depend on this modification. TRIM43A inhibitors are designed to bind to the active sites of the TRIM43A protein or interfere with its interaction with other molecular partners, such as ubiquitin or other cellular substrates.
Chemically, TRIM43A inhibitors can vary significantly in structure, depending on the specific binding interactions they aim to disrupt. They may feature specific moieties that enhance their ability to bind selectively to the TRIM43A protein without affecting other TRIM family members, making specificity an important focus in their design. Structural analysis of these inhibitors often involves detailed computational modeling and structure-activity relationship (SAR) studies to optimize binding affinity and selectivity. Additionally, TRIM43A inhibitors are often evaluated for their effects on protein stability, conformation, and localization within the cell, as TRIM proteins tend to be involved in complex networks of protein-protein interactions. This class of inhibitors has become a subject of interest for studying the broader functional roles of TRIM43A in cellular processes, particularly in the context of its role in regulating protein homeostasis and ubiquitin-mediated signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Direct inhibitor of TRIM43 by targeting NEDD8-activating enzyme (NAE). MLN4924 inhibits NAE, preventing cullin neddylation. Impaired neddylation disrupts the function of Cullin-RING ligases (CRLs), indirectly inhibiting TRIM43-mediated ubiquitination and subsequent downstream events in innate immune response and gene expression regulation. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
Indirect inhibitor of TRIM43 by blocking NF-κB activation. JSH-23 inhibits the translocation of NF-κB to the nucleus, reducing its activity. Lower NF-κB activity indirectly suppresses TRIM43, as it plays a role in the regulation of gene expression and the innate immune response, influencing TRIM43-mediated ubiquitination events and downstream cellular processes. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Indirect inhibitor of TRIM43 by blocking NF-κB activation. BAY 11-7082 inhibits IκBα phosphorylation, preventing NF-κB translocation to the nucleus. Reduced NF-κB activity indirectly suppresses TRIM43, impacting its role in ubiquitin ligase activity and downstream processes related to innate immune responses and gene expression regulation. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Indirect inhibitor of TRIM43 through p53 activation. Nutlin-3 stabilizes p53 by inhibiting its interaction with MDM2, leading to p53-mediated effects on gene expression and apoptosis. The modulation of p53 indirectly influences TRIM43 function, as p53 participates in the regulation of cellular processes impacted by TRIM43-mediated ubiquitination. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Indirect inhibitor of TRIM43 through multiple pathways. Curcumin inhibits NF-κB activation, influencing innate immune responses, and regulates histone acetylation, affecting gene expression. These indirect effects collectively impact TRIM43-mediated ubiquitination, contributing to the overall regulation of innate immune responses and gene expression. | ||||||
[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone | 873225-46-8 | sc-503387 | 10 mg | $430.00 | ||
Indirect inhibitor of TRIM43 through NF-κB pathway modulation. IKK Inhibitor VII inhibits IκBα phosphorylation, preventing NF-κB activation. Lower NF-κB activity indirectly suppresses TRIM43, affecting its role in ubiquitin ligase activity and influencing downstream events in innate immune responses and gene expression regulation. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Indirect inhibitor of TRIM43 through redox modulation. Auranofin induces oxidative stress, influencing cellular redox balance. Altered redox conditions indirectly impact TRIM43-mediated ubiquitination and downstream cellular processes related to the innate immune response and gene expression regulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Direct inhibitor of TRIM43 through proteasome inhibition. MG-132 prevents the degradation of ubiquitinated proteins by inhibiting the proteasome. This leads to the accumulation of ubiquitinated substrates, impacting TRIM43-mediated ubiquitination and its downstream effects on innate immune responses and gene expression regulation. | ||||||
SMER28 | 307538-42-7 | sc-222320 | 10 mg | $173.00 | ||
Indirect inhibitor of TRIM43 through autophagy modulation. SMER28 induces autophagy, influencing the turnover of cellular components. Altered autophagic activity indirectly impacts TRIM43-mediated ubiquitination, as autophagy is intricately connected to the regulation of innate immune responses and gene expression. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Indirect inhibitor of TRIM43 through autophagy modulation. Bafilomycin A1 inhibits autophagosome-lysosome fusion, impacting the autophagic degradation of cellular components. Altered autophagy levels indirectly influence TRIM43-mediated ubiquitination and downstream cellular processes related to the innate immune response and gene expression regulation. | ||||||