TRIM30C Activators
TRIM30C, a member of the tripartite motif (TRIM) protein family, plays a crucial role in cellular processes by acting as a regulator of immune responses and inflammatory pathways. The target protein is involved in various signaling cascades and cellular functions, contributing to the maintenance of cellular homeostasis. Functionally, TRIM30C exhibits E3 ubiquitin ligase activity, participating in the ubiquitination of specific substrates involved in immune regulation and cellular stress responses.
Activation of TRIM30C is intricately linked to several signaling pathways and molecular interactions within the cellular milieu. The presented chemicals exert their influence on TRIM30C either directly or indirectly, targeting specific pathways to enhance its expression and subsequent activation. For instance, resveratrol positively modulates the SIRT1/AMPK pathway, resulting in increased TRIM30C levels. Quercetin stimulates the Nrf2 pathway, enhancing TRIM30C transcription and activation. Curcumin indirectly activates TRIM30C by suppressing the NF-κB pathway, relieving its inhibitory effect on TRIM30C expression. Oleanolic acid, genistein, sulforaphane, dioscin, betulinic acid, baicalein, ursolic acid, indole-3-carbinol, and kaempferol each contribute to TRIM30C activation through distinct pathways, thereby expanding the regulatory network of this pivotal protein. The intricate interplay between these chemicals and specific signaling cascades results in the modulation of TRIM30C expression, highlighting the versatility of these compounds in influencing cellular processes related to immune response, inflammation, apoptosis, and stress response. The presented chemicals offer valuable insights into potential avenues for manipulating TRIM30C activation, paving the way for further exploration of its roles in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, activates TRIM30C by modulating the SIRT1/AMPK pathway. It up-regulates TRIM30C expression by enhancing SIRT1 activity, which promotes AMPK phosphorylation, leading to TRIM30C activation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin acts as a direct activator of TRIM30C by positively influencing the Nrf2 signaling pathway. By stimulating Nrf2, it enhances the transcription of TRIM30C, resulting in increased protein levels and subsequent activation, supporting cellular homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin functions as an indirect activator of TRIM30C through inhibition of the NF-κB pathway. By suppressing NF-κB activity, curcumin relieves its inhibitory effect on TRIM30C expression, allowing for increased levels of the protein and subsequent activation. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic acid, a triterpenoid, activates TRIM30C by positively modulating the AKT/mTOR pathway. It enhances AKT phosphorylation, leading to increased mTOR activation, which in turn up-regulates TRIM30C expression, promoting its activation and cellular functions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein acts as a direct activator of TRIM30C by promoting its expression through the estrogen receptor (ER) pathway. By binding to ER, genistein induces the transcription of TRIM30C, resulting in elevated protein levels and subsequent activation of its cellular functions. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane serves as an indirect activator of TRIM30C by influencing the Keap1/Nrf2 pathway. By promoting Nrf2 translocation, sulforaphane enhances the expression of TRIM30C, leading to its activation and subsequent engagement in cellular processes, including stress response. | ||||||
Dioscin | 19057-60-4 | sc-497470 | 25 mg | $380.00 | ||
Dioscin activates TRIM30C by positively modulating the JAK/STAT pathway. It enhances STAT3 phosphorylation, leading to increased transcription of TRIM30C and subsequent up-regulation, promoting its activation in cellular processes related to immune response and inflammation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid functions as a direct activator of TRIM30C by influencing the p53 pathway. By promoting p53 stabilization, it enhances the transcriptional activation of TRIM30C, leading to increased protein levels and subsequent engagement in cellular processes related to apoptosis. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein acts as an indirect activator of TRIM30C by inhibiting the Wnt/β-catenin pathway. Through suppression of β-catenin, baicalein relieves its inhibitory effect on TRIM30C expression, resulting in increased protein levels and subsequent activation in cellular processes related to cell cycle regulation. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid serves as a direct activator of TRIM30C by modulating the Hedgehog signaling pathway. It enhances Hedgehog pathway activity, leading to increased TRIM30C expression and subsequent activation, promoting its engagement in cellular processes related to development and tissue homeostasis. | ||||||