TRIM23 Activators
TRIM23 activators encompass a spectrum of chemical compounds that each contribute to augmenting the functional activity of TRIM23 through various biochemical pathways. Forskolin, with its ability to activate adenylate cyclase, and 8-Br-cAMP, as a phosphodiesterase-resistant analog of cAMP, both elevate intracellular cAMP levels, leading to the activation of PKA. The activated PKA can phosphorylate proteins that either interact with TRIM23 or are part of its regulatory network, enhancing TRIM23's ubiquitin ligase activity. Ionomycin and A23187, by increasing intracellular calcium, activate calcium-dependent kinases such as CaMK, which may phosphorylate key substrates or co-factors that modulate TRIM23's activity. PMA, through PKC activation, and LY294002, by inhibiting PI3K, alter downstream proteins and pathways that could increase the functional activity of TRIM23, potentially by modifying its interaction with target proteins or by altering its regulatory mechanisms.
The impact of these activators continues with IBMX, which raises cAMP levels and thereby potentiates the effects of PKA on the TRIM23 pathway, and Calyculin A, which prevents the dephosphorylation of proteins within the TRIM23 interaction network. Epigallocatechin gallate, by inhibiting certain kinases, and Okadaic acid, as an inhibitor of phosphatases, both lead to changes in the phosphorylation state of proteins involved in TRIM23's pathway, thus enhancing its activity. Spermidine facilitates TRIM23's role in autophagy by activating AMPK and promoting autophagic processes, which are crucial for cellular homeostasis and protein turnover. Lastly, Anisomycin, by triggering the MAPK pathway, can enhance TRIM23 activity as the cell responds to the stress of inhibited protein synthesis, highlighting the dynamic interplay between protein degradation and synthesis in which TRIM23 is a key regulatory component.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels within the cell. This elevation of cAMP indirectly enhances the activity of TRIM23 by activating protein kinase A (PKA), which can phosphorylate downstream proteins that may interact with TRIM23, enhancing its E3 ubiquitin ligase activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium can activate calcium/calmodulin-dependent protein kinase (CaMK), which may then phosphorylate substrates that interact with or modify TRIM23 activity, thereby enhancing its function. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog is resistant to degradation by phosphodiesterases and thus serves to activate PKA over prolonged periods. The sustained PKA activity can lead to the phosphorylation of proteins that regulate TRIM23, enhancing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) which is involved in a wide array of cellular functions. Activation of PKC can lead to the modification of proteins that are part of the TRIM23-regulated pathways, resulting in the enhancement of TRIM23's E3 ligase activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels. The increase in calcium can stimulate various calcium-dependent kinases, potentially enhancing the interaction of TRIM23 with its substrates or co-factors and thus its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels. This increase can potentiate PKA activity, which may result in the phosphorylation of proteins that modulate TRIM23 activity, enhancing its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 can modulate the PI3K/AKT pathway, which is involved in various cellular processes. Inhibition of this pathway can lead to alterations in downstream signaling that could enhance the activity of TRIM23 by relieving negative regulation or by modifying interacting proteins. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
This compound is a serine/threonine phosphatase inhibitor that prevents the dephosphorylation of proteins, which could include substrates or regulators of TRIM23. By maintaining the phosphorylation state of these proteins, Calyculin A indirectly enhances the activity of TRIM23. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with various biological effects. It has been shown to inhibit certain kinases, which could lead to the activation of signaling pathways involving TRIM23, thereby potentially enhancing its ubiquitination activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
This compound is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can lead to increased phosphorylation levels of proteins within TRIM23 pathways, enhancing its activity by altering its interaction with other proteins. | ||||||