TRIM23 Inhibitors
Chemical inhibitors of TRIM23 function by impeding the ubiquitin-proteasome system (UPS), which is essential for protein degradation. These compounds effectively block the proteolytic activity within the UPS, thereby preventing TRIM23 from fulfilling its role in tagging defective or unneeded proteins for degradation. MG-132, for example, is a proteasome inhibitor that can prevent the breakdown of ubiquitin-conjugated proteins, including those targeted by TRIM23. Similarly, Lactacystin functions by inhibiting the proteasome, leading to the accumulation of proteins that would typically be degraded with the assistance of TRIM23, disrupting its role in protein quality control.
Other inhibitors such as Epoxomicin, Bortezomib, and Velcade (which is another name for Bortezomib), target the 26S proteasome, specifically inhibiting the degradation of ubiquitinated proteins and indirectly inhibiting TRIM23's functional role in protein turnover. Carfilzomib and Oprozomib, also proteasome inhibitors, can halt the breakdown of proteins tagged by TRIM23, affecting the protein homeostasis that TRIM23 helps to maintain. Marizomib and NPI-0052, which is an alternative name for Marizomib, block the proteolytic degradation of proteins within the pathway involving TRIM23, thus affecting its role in protein turnover and cellular homeostasis. Lastly, MLN2238, known as Ixazomib, and Delanzomib, both inhibit the 20S proteasome, leading to the buildup of proteins marked by TRIM23 for degradation and thereby inhibiting TRIM23's function in the protein degradation process. Each of these inhibitors operates by disrupting the normal function of the proteasome, leading to an accumulation of proteins that would otherwise be degraded, directly affecting TRIM23's ability to regulate protein turnover within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
As a proteasome inhibitor, MG-132 can inhibit the degradation pathway that TRIM23 relies on to mediate the turnover of specific proteins. By blocking the proteasome, it prevents the breakdown of ubiquitin-conjugated proteins that TRIM23 may target. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin inhibits the proteasome, leading to the accumulation of proteins that TRIM23 would typically help degrade. This accumulation can inhibit TRIM23 function by disrupting its role in protein quality control and degradation. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
This compound is a selective proteasome inhibitor that can inhibit the degradation of proteins targeted by TRIM23, thereby inhibiting TRIM23's function by preventing the proteolytic processing of substrates TRIM23 has tagged for degradation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib targets the 26S proteasome, inhibiting the degradation of ubiquitinated proteins. It can inhibit TRIM23 function by blocking the proteolytic activity that TRIM23 is involved in, leading to an indirect inhibition of TRIM23's role in protein turnover. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Carfilzomib, a proteasome inhibitor, can inhibit TRIM23 function by impeding the breakdown of proteins that TRIM23 marks for degradation, thus affecting the protein homeostasis that TRIM23 is involved in maintaining. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
As an inhibitor of the 20S proteasome, Oprozomib can inhibit TRIM23's function by preventing the proteolysis of ubiquitinated proteins, which TRIM23 may have tagged for degradation, thus disrupting TRIM23's regulatory role in protein degradation. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
MLN2238, also known as Ixazomib, inhibits the 20S proteasome, leading to the buildup of proteins tagged by TRIM23 for degradation and thereby inhibiting TRIM23's function in the process of protein degradation. | ||||||
Delanzomib, free base | 847499-27-8 | sc-396774 sc-396774A | 5 mg 10 mg | $160.00 $300.00 | ||
Delanzomib is a proteasome inhibitor that can inhibit TRIM23 function by preventing the breakdown of proteins tagged by TRIM23 for ubiquitination and subsequent degradation, affecting the protein degradation pathway TRIM23 is involved in. | ||||||