TRAX Inhibitors
TRAX inhibitors are a specialized class of chemical compounds designed to target the TRAX protein. TRAX, also known as Trans-Activation Response RNA-Binding Protein, is a multifunctional protein that plays a role in RNA metabolism and gene expression regulation. It is part of a ribonucleoprotein complex that includes the protein Dicer and small RNA molecules called precursor microRNAs (pre-miRNAs). This complex is essential for the processing of pre-miRNAs into mature microRNAs (miRNAs), which are small non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to messenger RNAs (mRNAs) and affecting their stability and translation.
Inhibitors targeting TRAX are designed to interact with this protein and potentially interfere with its function in the miRNA processing pathway. These inhibitors may operate through various mechanisms, such as binding to specific regions of TRAX or altering its conformation. By inhibiting TRAX, these compounds can potentially disrupt the processing of pre-miRNAs into mature miRNAs, affecting the cellular miRNA repertoire and ultimately influencing gene expression patterns. Research on TRAX inhibitors is primarily focused on elucidating the molecular mechanisms by which TRAX participates in miRNA biogenesis and its role in regulating gene expression, contributing to our understanding of post-transcriptional gene regulation and RNA metabolism.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide with a broad effect on transcription, potentially lowering TRAX expression via RNA polymerase inhibition. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that could hypothetically modulate gene expression and mRNA stability, affecting TRAX levels indirectly. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
An endocrine disruptor that may alter gene expression through epigenetic modifications, potentially reducing TRAX expression. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 25 g 100 g 500 g | $41.00 $61.00 $194.00 | 11 | |
Overdose has been shown to deplete glutathione and could alter cellular redox states, affecting gene expression indirectly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that incorporates into DNA and RNA, it could disrupt epigenetic regulation, potentially downregulating TRAX. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, this compound could induce hypomethylation of DNA, potentially affecting TRAX gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, which could change chromatin structure around the TRAX gene, possibly reducing expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor known to alter gene expression, which could theoretically affect TRAX. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
A compound that binds to DNA and could inhibit transcription factor binding, potentially downregulating TRAX. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can broadly affect gene expression, potentially inhibiting TRAX expression indirectly. | ||||||