TRAX Antibody (B-10): sc-271402

TRAX Antibody (B-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects TRAX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TRAX antibody (B-10) is available as the non-conjugated form. TRAX, also known as translin-associated factor X or TSNAX, is a crucial nuclear protein that plays a significant role in cellular response to DNA damage. TRAX (B-10) antibody targets a protein primarily located in the nucleus, where TRAX interacts with translin, a DNA-binding protein essential for repairing chromosomal translocations. TRAX presence in the nucleus is vital for function in DNA double-stranded break repair and dendritic RNA processing, as TRAX facilitates recruitment of other proteins involved in these processes. TRAX contains an N-terminal bipartite nuclear localization signal (NLS) that aids in nuclear transport, as well as a leucine zipper domain critical for protein-protein interactions. When TRAX forms a complex with translin, TRAX can interact with protein kinase activator C1D, enhancing the complex′s ability to participate in DNA repair mechanisms. TRAX acts as a transcriptional regulator of GAP-43, a growth-associated protein implicated in axonal regeneration and cell proliferation, highlighting TRAX potential importance in neurodevelopment and recovery following injury.

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TRAX Antibody (B-10) References:

1. Trax is a component of the Translin-containing RNA binding complex.  |  Finkenstadt, PM., et al. 2002. J Neurochem. 83: 202-10. PMID: 12358744
2. Identification of Translin/Trax complex as a glucose response element binding protein in liver.  |  Wu, RF., et al. 2003. Biochim Biophys Acta. 1624: 29-35. PMID: 14642810
3. The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells.  |  Cho, YS., et al. 2004. J Biol Chem. 279: 31514-23. PMID: 15138261
4. KIF2Abeta: A kinesin family member enriched in mouse male germ cells, interacts with translin associated factor-X (TRAX).  |  Bray, JD., et al. 2004. Mol Reprod Dev. 69: 387-96. PMID: 15457513
5. Co-expressed recombinant human Translin-Trax complex binds DNA.  |  Gupta, GD., et al. 2005. FEBS Lett. 579: 3141-6. PMID: 15919079
6. Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.  |  Laufman, O., et al. 2005. Nucleic Acids Res. 33: 4128-39. PMID: 16043634
7. Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X.  |  Sun, CN., et al. 2006. Mol Pharmacol. 70: 454-66. PMID: 16617164
8. Functional characterization of Drosophila Translin and Trax.  |  Claussen, M., et al. 2006. Genetics. 174: 1337-47. PMID: 17028328
9. Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration.  |  Schröer, U., et al. 2007. Eur J Neurosci. 26: 2169-78. PMID: 17953615

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRAX Antibody (B-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TRAX Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRAX Antibody (B-10) Specifications

Alternate Product Name: TRAX

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-290

Epitope Target: TRAX

Epitope Species: human

Product Reactivity/Detection: TRAX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TRAX Antibody (B-10): X: TransCruz Reagent