Trav3d-3 Activators
The chemical class known as TRAV3D-3 Activators encompasses a range of compounds that can modulate intracellular signaling pathways, which are crucial for the activation of T cells, including those with the TRAV3D-3 segment. These activators work by influencing various molecules and enzymes that are implicated in the cascade of events leading to T cell activation. The activation of T cells is a complex process that requires the precise coordination of signaling pathways, and these activators can alter the behavior of these pathways, leading to changes in T cell function. This class includes kinase inhibitors, ionophores, and various other signaling modulators.
Each member of the TRAV3D-3 Activators class operates within the cellular environment to modulate specific signaling molecules or pathways. For instance, some activators target kinases that are directly involved in the signal transduction from the T cell receptor, effectuating a change in the T cell's response. Others may interact with key regulatory enzymes that control the levels of secondary messengers, such as cAMP, within the cell, thereby adjusting the signaling dynamics. These changes can result in the amplification of signals that are essential for the full activation of T cells. This class is characterized by its ability to act on various points of the signaling network that T cells employ, from the early stages of receptor engagement to the downstream transcriptional events that ultimately lead to cellular responses. By doing so, they can alter the functional state of T cells in a manner that is congruent with the activation process initiated by the engagement of a T cell receptor, such as one that includes TRAV3D-3.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC), which is a kinase involved in TCR signaling. Activation of PKC could possibly activate T cells with TRAV3D-3 through downstream signaling events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which could possibly activate T cells with TRAV3D-3 by mimicking the TCR-mediated signaling that leads to activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which could possibly activate T cells with TRAV3D-3 by modulating TCR signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in T cell metabolism and function. Inhibition of this pathway could possibly activate T cells with TRAV3D-3 by influencing their activation states. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could possibly activate T cells with TRAV3D-3 by affecting the MAPK pathway, which is involved in T cell activation and differentiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, affecting the PI3K-Akt pathway. Inhibition of PI3K could possibly activate T cells with TRAV3D-3 by influencing T cell survival, growth, and activation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases and could possibly activate T cells with TRAV3D-3 by altering TCR signaling through inhibition of Lck and Fyn. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, which is important for NFAT activation. Inhibition of calcineurin could possibly activate T cells with TRAV3D-3 by modulating T cell activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which could possibly activate T cells with TRAV3D-3 by influencing TCR signaling and T cell activation through the MAPK pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that could possibly activate T cells with TRAV3D-3 by leading to changes in TCR signaling through the MAPK/ERK pathway. | ||||||