Tra-2α Activators
The chemicals identified as Tra-2α Activators are an ensemble of compounds that function primarily through the elevation of intracellular cAMP levels or the inhibition of cAMP degradation, leading to enhanced protein kinase A (PKA) activity. These compounds, ranging from neurotransmitters and hormones like epinephrine and dopamine to phosphodiesterase inhibitors such as IBMX and theophylline, converge on the activation of PKA. PKA is a key signaling molecule that phosphorylates a variety of substrates within the cell, influencing numerous cellular processes. The activation of PKA by these chemicals can result in the phosphorylation of target proteins that either directly or indirectly modulate the activity of Tra-2α. This modulation could be due to changes in the phosphorylation status of Tra-2α itself or alterations in the activity of proteins that interact with or regulate Tra-2α.
The broad spectrum of these compounds reflects the wide-ranging mechanisms through which cAMP-PKA signaling can be modulated. For instance, forskolin directly stimulates adenylate cyclase to produce cAMP, while IBMX and rolipram prevent the breakdown of cAMP, thereby sustaining its signaling capabilities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can enhance PKA activity, potentially resulting in phosphorylation events that may lead to increased activity of Tra-2α. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective phosphodiesterase inhibitor, raises intracellular cAMP levels, potentially enhancing PKA activity and leading to the modulation of Tra-2α activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Phosphodiesterase-4 inhibitor, increases cAMP concentrations, possibly leading to downstream effects that enhance Tra-2α activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Activates cAMP-PKA signaling through its receptors, which may subsequently influence the phosphorylation status and activity of Tra-2α. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Activates adrenergic receptors, leading to increased cAMP and activation of PKA, potentially enhancing Tra-2α activity through phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
β-adrenergic agonist, increases cAMP levels and activates PKA, potentially resulting in enhanced phosphorylation and activity of Tra-2α. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Binds to dopamine receptors influencing cAMP production, possibly affecting Tra-2α activity through PKA-mediated pathways. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Activates G-protein-coupled histamine receptors, can lead to increased cAMP and PKA activity, potentially modulating Tra-2α activity. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Acts on serotonin receptors, leading to increased cAMP and PKA activation, which may affect the phosphorylation and activity of Tra-2α. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Through its receptors, adenosine can increase cAMP levels, which might lead to PKA activation and subsequent modulation of Tra-2α activity. | ||||||