TPBG Inhibitors
Chemical inhibitors of TPBG can exert their inhibitory effects through various mechanisms that disrupt specific cellular pathways in which TPBG is involved. Colchicine, for example, is known to disrupt microtubule polymerization. This action has significant consequences on the cytoskeletal dynamics that are crucial for the functioning of TPBG, particularly in processes like cell adhesion and migration. Similarly, Cytochalasin D, by inhibiting actin polymerization, can alter the cellular architecture and processes that are essential for TPBG's function, such as cytokinesis. On the other hand, Blebbistatin, by inhibiting myosin II, can hinder TPBG's involvement in cell motility and invasion, which are critical for its functional expression in cellular activities.
Moreover, small molecule inhibitors like PD173074, which target FGFR, can disrupt the signaling pathways that TPBG uses for cell survival and proliferation. Y-27632, a ROCK inhibitor, can interfere with TPBG's role in cell morphology and motility through the Rho-associated kinase signaling pathway. LY294002 and Wortmannin, both PI3K inhibitors, can disrupt TPBG's role in signaling pathways integral to cell growth and survival. Similarly, U0126, a MEK inhibitor, can disrupt the ERK signaling pathways that TPBG may interact with, particularly those involved in cell differentiation. Rapamycin, an mTOR inhibitor, can affect TPBG's related pathways that regulate cell growth, proliferation, and survival. SB431542, by inhibiting the TGF-β receptor, can disrupt the signaling pathways associated with TPBG that are relevant to cell growth and differentiation. ZM447439, as an Aurora kinase inhibitor, can impede TPBG's role during cell division and maintenance of mitotic spindle integrity. Lastly, SU5402, by inhibiting FGF receptors, can hinder the TPBG function in cell migration and wound healing processes. Each of these chemicals targets specific cellular pathways or structural components that are crucial for the functional expression of TPBG, leading to its inhibition.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization, which can inhibit TPBG's function in cell adhesion and migration by altering the cytoskeletal dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which can impact TPBG's role in cellular processes like cytokinesis, affecting its functional roles. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
By inhibiting myosin II, Blebbistatin can inhibit TPBG's involvement in cell motility and invasion, processes critical for its function. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
PD173074, an FGFR inhibitor, can inhibit TPBG by blocking pathways involved in cell survival and proliferation where TPBG is known to have a role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
As a ROCK inhibitor, Y-27632 can inhibit TPBG's role in cell morphology and motility through the Rho-associated kinase signaling pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, potentially inhibiting TPBG's role in signaling pathways related to cell growth and survival. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, which can lead to inhibition of TPBG's function by disrupting signaling pathways it participates in. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK, which can lead to inhibition of TPBG by disrupting downstream ERK signaling pathways involved in cell differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which can inhibit TPBG's function related to cell growth, proliferation, and survival signaling pathways. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is an inhibitor of TGF-β receptor, which can inhibit TPBG's function in signaling pathways related to cell growth and differentiation. | ||||||