TorsinB Inhibitors
TorsinB inhibitors represent a class of chemical compounds designed to modulate the activity of the TorsinB protein, a member of the AAA+ (ATPases associated with diverse cellular activities) family. The Torsin family of proteins plays a crucial role in cellular processes, particularly in the endoplasmic reticulum and nuclear envelope, where they are involved in protein folding and trafficking. TorsinB, specifically, is located within the endoplasmic reticulum and is implicated in various cellular functions related to protein quality control and organelle integrity.The development of TorsinB inhibitors stems from a growing interest in understanding the functional significance of Torsin proteins and their potential as targets.
Researchers have explored small molecules that can selectively modulate the activity of TorsinB, aiming to unravel its precise biological roles and pave the way for future investigations into the broader implications of TorsinB inhibition. By elucidating the intricate regulatory mechanisms governing TorsinB function, scientists anticipate gaining valuable insights into cellular processes and, potentially, uncovering new avenues for intervention in various diseases. The chemical class of TorsinB inhibitors thus represents a promising area of research for unraveling the complexities of cellular biology and expanding our knowledge of protein regulation within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a general tyrosine phosphatase inhibitor. It can indirectly affect TorsinB since TorsinB plays a role in cytoskeletal organization and phosphorylation events. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), and can influence TorsinB indirectly, given its involvement in cellular processes that require these phosphatases. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a broad-spectrum tyrosine kinase inhibitor. Given that TorsinB might be involved in signal transduction pathways that require tyrosine kinase activity, Genistein can indirectly affect TorsinB activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and selective inhibitor of PI3K, which can indirectly influence TorsinB, assuming the protein's involvement in signaling pathways that require PI3K. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC, PKA, and PKG, which can indirectly affect TorsinB, given its involvement in cellular processes that require these kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, thus indirectly affecting TorsinB if it's involved in signaling pathways that require PI3K. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which can indirectly influence TorsinB, given its potential involvement in signaling pathways that require MEK. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK, which can indirectly influence TorsinB, given its potential involvement in signaling pathways that require JNK. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, which can indirectly affect TorsinB, assuming its involvement in similar signaling pathways. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of CaMKII, and can indirectly influence TorsinB, assuming the protein's involvement in signaling pathways that require CaMKII. | ||||||