Tor1 Activators
The class of chemicals known as Tor1 Activators consists of compounds that primarily act on the PI3K/Akt pathway, the cAMP/PKA pathway, or the intracellular level of essential amino acids or glucose, leading to the indirect activation of Tor1. Tor1 is part of the TORC1 complex that is regulated by these pathways. The first group of activators form part of the PI3K/Akt pathway, which leads to the inhibition of the TSC1/2 complex, a negative regulator of the TOR pathway. This removes the inhibitory effect on Tor1, leading to its activation. Activators of this class also interact with the TOR pathway through the Rag GTPases and AMPK, respectively. They activate the TOR pathway when intracellular levels of amino acids are high, while glucose does so by increasing the cellular energy level, which is sensed directly by AMPK.
Tor1 Activators enhance the cAMP/PKA pathway, causing the PKA-dependent inhibition of the TSC1/2 complex, leading to the activation of Tor1. They also act on acetyltransferase EP300 and Sirt. A small group of activators in this class exert their effects on Tor1 through more unique mechanisms. They inhibit acetyltransferase EP300, leading to the deacetylation of TSC2, a component of the TSC1/2 complex, which negatively regulates the TOR pathway, including Tor1. Laslty, activators of this class also inhibit Sirt1, a positive regulator of TSC2, thus activating the mTOR pathway and Tor1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can activate the PI3K/Akt pathway, which in turn can stimulate the TORC1 complex that includes Tor1. This activation occurs through the inhibition of TSC1/2, a negative regulator of Tor1. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
Leucine is an essential amino acid that activates the mTOR pathway, including Tor1, through the Rag GTPases, which are directly sensitive to the intracellular level of amino acids. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose stimulates the TOR pathway, including Tor1, by increasing the cellular energy level, which is sensed directly by AMPK, a negative regulator of the TOR pathway. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA is a bioactive phospholipid that activates the mTOR pathway, including Tor1, through its action on the PI3K/Akt pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates the mTOR pathway, including Tor1, through its action on protein kinase C (PKC), which can stimulate the PI3K/Akt pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, causing an increase in cAMP levels, which can activate the mTOR pathway, including Tor1, through the PKA-dependent inhibition of TSC1/2. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine can inhibit acetyltransferase EP300, leading to the deacetylation of TSC2, a component of the TSC1/2 complex, which negatively regulates the mTOR pathway including Tor1. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II can activate the mTOR pathway including Tor1, through its action on the PI3K/Akt pathway. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide can inhibit Sirt1, a positive regulator of TSC2, leading to the activation of the mTOR pathway including Tor1. | ||||||
PACAP(6-38) | 137061-48-4 | sc-391136 sc-391136A | 500 µg 1 mg | $540.00 $932.00 | ||
PACAP can activate the mTOR pathway including Tor1, through its action on the cAMP/PKA pathway, leading to the inhibition of TSC1/2. | ||||||