Top1 Activators
Top1, or DNA topoisomerase I, is a crucial enzyme in the cellular machinery of eukaryotic organisms. It plays an indispensable role in DNA transcription, replication, and repair by creating transient single-strand breaks in the helix of DNA, allowing for the necessary relaxation of supercoils that form during these vital processes. The activity of Top1 ensures that the DNA double helix can be properly unwound and re-wound, maintaining the integrity of genetic information during cell division and cellular response to stress. The precise regulation of Top1 expression is pivotal for the maintenance of genomic stability, as both its overexpression and deficiency can lead to genomic instability and altered cellular function. Given its central role in maintaining DNA integrity, the expression of Top1 is a tightly regulated process that can be influenced by a myriad of intracellular and extracellular signals, including the exposure to specific chemical compounds.
Certain chemical compounds have been identified to potentially induce the expression of Top1. These activators often interact with cellular DNA or influence the DNA damage response mechanisms, leading to an upsurge in the production of Top1. For instance, compounds that intercalate with DNA, such as ellipticine, can disrupt the normal topological state of DNA, which may stimulate the cell to increase Top1 expression to counteract these changes. Similarly, agents that inhibit related enzymes, like topoisomerase II inhibitors, may lead to a compensatory rise in Top1 levels as the cell seeks to maintain the equilibrium of its topoisomerase activities. Such chemical interactions are a testament to the dynamic nature of cellular responses, highlighting the sophisticated network of feedback and regulatory mechanisms that govern protein expression. Through understanding the relationship between these chemical compounds and the expression of Top1, researchers continue to uncover the intricate web of cellular adaptation and the maintenance of genomic fidelity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin binds irreversibly to the Top1-DNA complex, leading to DNA strand breaks. Cells may respond by elevating Top1 synthesis to overcome the resulting DNA damage. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide targets DNA topoisomerase II, causing double-strand DNA breaks. The ensuing DNA damage response could include the upsurge of Top1 expression for damage remediation. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and hinders transcription and replication, prompting a cellular defense mechanism that may stimulate the synthesis of Top1 to aid in DNA repair. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
By intercalating with DNA strands, Ellipticine disrupts normal DNA function, which may provoke a cellular counteraction manifesting as an increase in Top1 production. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine's ability to intercalate into DNA and disrupt normal cellular processes could compel the cell to elevate Top1 levels as a reparative measure. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone forms complexes with DNA and inhibits topoisomerase II, potentially triggering a surge in Top1 expression to compensate for the impaired DNA relaxation. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine’s interaction with DNA topoisomerase II might precipitate DNA damage, inciting a cellular response that includes the amplification of Top1 expression. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Similar to etoposide, Teniposide impedes topoisomerase II, possibly inciting a boost in Top1 levels as part of the cellular contingency to repair DNA. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A chelates with DNA, potentially setting off a cascade of DNA repair processes that may escalate Top1 expression to counteract DNA damage signals. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA polymerase, leading to transcription stress that could provoke an upregulation of Top1 to stabilize the DNA during repair and replication. | ||||||