Molecular structure of Teniposide, CAS Number: 29767-20-2
Teniposide (CAS 29767-20-2)
See product citations (6)
Application:
Teniposide is a derivative of podophyllotoxin that has shown cytostatic effect & inhibition of topoisomerase II
CAS Number:
29767-20-2
Purity:
≥97%
Molecular Weight:
656.7
Molecular Formula:
C32H32O13S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Teniposide is a glycoside-derivative of podophyllotoxin, has cytostatic effect. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA. That results in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. Acts in the late S or early G phase of the cell cycle.
Teniposide (CAS 29767-20-2) References
- Mechanisms of action of teniposide (VM-26) and comparison with etoposide (VP-16). | Long, BH. 1992. Semin Oncol. 19: 3-19. PMID: 1329225
- Teniposide in the treatment of small cell lung cancer: a review. | Hansen, HH., et al. 1992. Semin Oncol. 19: 65-8. PMID: 1329227
- Teniposide alone and in combination chemotherapy in small cell lung cancer. | Giaccone, G. 1992. Semin Oncol. 19: 75-80. PMID: 1329229
- Teniposide in adult solid tumors: a historical perspective. | Muggia, FM. and Kelley, SL. 1992. Semin Oncol. 19: 43-50. PMID: 1411638
- Clinical trials of teniposide (VM-26) in childhood acute lymphocytic leukemia. | Rivera, GK. and Evans, WE. 1992. Semin Oncol. 19: 51-8. PMID: 1411639
- Teniposide in lymphomas and leukemias. | Sonneveld, P. 1992. Semin Oncol. 19: 59-64. PMID: 1411640
- Teniposide (VM-26) in brain tumors. | McVie, JG. 1992. Semin Oncol. 19: 85-8. PMID: 1411642
- Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner. | Han, H., et al. 2018. Biochem Biophys Res Commun. 506: 1040-1046. PMID: 30409428
- Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics. | Holthuis, JJ. 1988. Pharm Weekbl Sci. 10: 101-16. PMID: 3047665
- Teniposide in the treatment of leukemia: a case study of conflicting priorities in the development of drugs for fatal diseases. | Grem, JL., et al. 1988. J Clin Oncol. 6: 351-79. PMID: 3276827
- Tellurophene-Tagging of Teniposide Facilitates Monitoring by Mass Cytometry. | Rana, R., et al. 2022. Chembiochem. 23: e202200284. PMID: 36040838
- Teniposide: overview of its therapeutic potential in adult cancers. | Muggia, FM. 1994. Cancer Chemother Pharmacol. 34 Suppl: S127-33. PMID: 8070021
Inhibitor of:
4930547C10Rik, C6orf167, DDX59, DNA pol β, DYDC1, Enzyme, FIGNL2, Gm498, hCAP-D2, Mad 4, Nop5, OBFC2B, OFCC1, Rec8, RecQL1, Ribosomal Protein L12, Rnr1, SSBP2, SWAP, THAP9, Top3, Topo II, Topo IIIβ, Tub, UIMC1, and XKRY2.Activator of:
4930547C10Rik, granzyme H, TDP2, and Top1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Teniposide, 25 mg | sc-204910 | 25 mg | $72.00 | |||
Teniposide, 100 mg | sc-204910A | 100 mg | $230.00 |