Tom40B activators represent a specialized class of chemical compounds that have garnered attention within the field of molecular biology and cellular processes. These compounds are meticulously designed to modulate the activity of Tom40B, a protein-coding gene with essential roles in cellular functions, particularly in the context of mitochondrial import and protein translocation. Tom40B, also known as Translocase of Outer Mitochondrial Membrane 40 Homolog B, is a component of the mitochondrial outer membrane, where it forms part of the protein translocase complex, facilitating the import of proteins into the mitochondria. Tom40B activators function by targeting specific regulatory elements within the Tom40B gene, often located in promoter or enhancer regions, with the primary aim of enhancing its transcription and subsequent translation into functional protein products.
The mechanisms through which Tom40B activators exert their effects may vary, but their central purpose is to act as molecular switches, amplifying the activity of Tom40B. Researchers are continually exploring the potential applications and implications of Tom40B activation, aiming to deepen our understanding of how this gene contributes to cellular processes, particularly within the context of mitochondrial protein import and the maintenance of mitochondrial function. This class of compounds holds promise for advancing our knowledge of mitochondrial biology, specifically focusing on the role of Tom40B in ensuring the proper import of proteins into this vital organelle, offering insights into the intricate mechanisms that govern mitochondrial homeostasis and cellular energy production. Tom40B activators serve as valuable tools in the ongoing exploration of molecular biology, providing opportunities to uncover the complex roles that Tom40B plays in cellular functions and its potential involvement in the intricate world of mitochondrial biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aminolevulinic Acid Hydrochloride Salt | 5451-09-2 | sc-262399 sc-262399A sc-262399B sc-262399C | 1 g 5 g 25 g 100 g | $41.00 $110.00 $320.00 $1400.00 | 2 | |
This compound is a precursor in heme synthesis and might stimulate mitochondrial biogenesis, potentially increasing TOMM40 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which could induce a cellular stress response that includes upregulation of mitochondrial proteins like TOMM40. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to activate sirtuins, which can lead to enhanced mitochondrial biogenesis and possibly TOMM40 expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
As a PPAR-γ agonist, pioglitazone has been shown to influence mitochondrial biogenesis, which may affect TOMM40 expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMPK which can lead to mitochondrial biogenesis, potentially impacting TOMM40 expression. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in redox reactions and its supplementation may enhance mitochondrial function and thus TOMM40 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can activate Nrf2, leading to a possible increase in mitochondrial biogenesis and TOMM40 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression, which might indirectly affect the expression of genes like TOMM40. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP uncouples oxidative phosphorylation, potentially increasing mitochondrial biogenesis and TOMM40 expression. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $290.00 | ||
MitoQ is targeted to mitochondria and could potentially enhance their biogenesis, impacting TOMM40 expression. | ||||||