TNIP2 (Abin-2) Inhibitors
TNIP2, also known as Abin-2, is a protein that plays a critical role in regulating inflammatory and immune responses. It functions as part of the A20 ubiquitin-editing complex, which is crucial for modulating NF-κB signaling, a key pathway in immune response and cell survival. TNIP2 interacts with polyubiquitin chains and A20, helping to control the ubiquitination and subsequent degradation of signaling molecules in the NF-κB pathway. Through this regulation, TNIP2 helps maintain immune system balance and excessive inflammation.
Targeting TNIP2 for disruption or inhibition presents potential strategies for diseases characterized by overactive NF-κB signaling. Small molecule inhibitors that can specifically target the interaction between TNIP2 and A20 or other components of the NF-κB pathway could be developed. Another approach involves the use of RNA interference (RNAi) techniques to reduce TNIP2 expression, thereby modulating the NF-κB signaling cascade.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Known to inhibit NF-κB activation by blocking the phosphorylation of IκBα. Since TNIP2 is involved in the NF-κB signaling pathway, BAY 11-7082 might indirectly affect its function. | ||||||
IKK Inhibitor X | 431898-65-6 | sc-221742 | 5 mg | $352.00 | 3 | |
Inhibitors of IKK (IκB kinase) can prevent NF-κB activation. Given TNIP2's role in the NF-κB pathway, these inhibitors might indirectly disrupt its function. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
Inhibitors of IKK (IκB kinase) can prevent NF-κB activation. Given TNIP2's role in the NF-κB pathway, these inhibitors might indirectly disrupt its function. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Used in the inflammatory bowel and rheumatoid arthritis, it has been found to inhibit NF-κB activation. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
A specific inhibitor of NF-κB nuclear translocation, thereby potentially affecting TNIP2-associated signaling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Found in feverfew (Tanacetum parthenium), it inhibits NF-κB activation and might indirectly affect TNIP2. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
An antioxidant that also acts as an inhibitor of NF-κB activation. | ||||||