Molecular structure of IKK Inhibitor X, CAS Number: 431898-65-6
IKK Inhibitor X (CAS 431898-65-6)
See product citations (3)
Alternate Names:
PS-1145
Application:
IKK Inhibitor X is a potent, ATP-competitive, and reversible inhibitor of IKK
CAS Number:
431898-65-6
Purity:
≥98%
Molecular Weight:
322.8
Molecular Formula:
C17H11ClN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IKK Inhibitor X is a cell-permeable β-carboline compound that exhibits anti-inflammatory properties. A potent, ATP-competitive, and reversible inhibitor of IKK. Inhibits cellular IκBα phosphorylation and NF-κB activation in vitro.
IKK Inhibitor X (CAS 431898-65-6) References
- NF-kappa B as a therapeutic target in multiple myeloma. | Hideshima, T., et al. 2002. J Biol Chem. 277: 16639-47. PMID: 11872748
- Novel IKK inhibitors: beta-carbolines. | Castro, AC., et al. 2003. Bioorg Med Chem Lett. 13: 2419-22. PMID: 12824047
- A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. | Wen, D., et al. 2006. J Pharmacol Exp Ther. 317: 989-1001. PMID: 16525037
- Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. | Catley, MC., et al. 2006. Mol Pharmacol. 70: 697-705. PMID: 16687566
- Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways. | Robertson, SA., et al. 2009. Regul Pept. 152: 41-7. PMID: 18722482
- Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis. | Mizumoto, Y., et al. 2011. Clin Cancer Res. 17: 1341-50. PMID: 21411444
- Intestinal myofibroblasts produce nitric oxide in response to combinatorial cytokine stimulation. | Wu, J., et al. 2013. J Cell Physiol. 228: 572-80. PMID: 22833357
- Lapatinib-induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors. | Chen, YJ., et al. 2013. Breast Cancer Res. 15: R108. PMID: 24216290
- IL-1β induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis. | Bernard, M., et al. 2017. J Pathol. 242: 234-245. PMID: 28191908
- Anti-inflammatory activity of CKC-containing cationic emulsion eye drop vehicles. | Daull, P., et al. 2018. Mol Vis. 24: 459-470. PMID: 30078983
Inhibitor of:
ANKRD29, APRIL-TWEAK, HSF2, IκB-α, IκB-β, IκB-δ, IK, IKIP, IKK, IKK beta, IKK-i, LOC643749, NKRF, RIG-I, SPATA2, and TNIP2 (Abin-2).Activator of:
oskar, and OTTMUSG00000011269.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKK Inhibitor X, 5 mg | sc-221742 | 5 mg | $352.00 |