TMPRSS11B Inhibitors
TMPRSS11B inhibitors encompass a range of compounds that specifically target the proteolytic activity of this serine protease. Gabexate Mesilate, Camostat Mesilate, and Nafamostat Mesilate are direct inhibitors that bind to the serine residue within TMPRSS11B's active site, effectively blocking its ability to cleave peptide bonds. Similarly, AEBSF and its structurally analogous compound, 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, covalently modify this crucial serine residue, leading to irreversible inactivation. Leupeptin Hemisulfate and Aprotinin are reversible inhibitors that compete with substrates for access to TMPRSS11B's active site, while Benzamidine Hydrochloride also targets the active site but with different binding interactions, all contributing to the reduction of TMPRSS11B's enzymatic function.
Expanding the scope to indirect inhibitors, compounds like E-64 and Pepstatin A, which are classically known for targeting cysteine and aspartic proteases respectively, may exert an influence on TMPRSS11B through their effects on interconnected proteolytic pathways. Sivelestat, a neutrophil elastase inhibitor, and Marimastat, a metalloprotease inhibitor, impact the protease-antiprotease balance and extracellular matrix remodeling, processes that could potentially alter TMPRSS11B's activity indirectly. Collectively, these inhibitors demonstrate the multifaceted approaches to modulating TMPRSS11B's function, ranging from direct active site blockade to indirect pathway interference, highlighting the complexity of protease regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
A serine protease inhibitor that directly impedes TMPRSS11B activity by binding to the serine residue in the active site of TMPRSS11B, leading to the inhibition of its proteolytic function. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
A serine protease inhibitor that blocks TMPRSS11B by inhibiting its enzymatic activity, which is essential for TMPRSS11B-mediated proteolytic processing of proteins. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
A serine protease inhibitor that prevents TMPRSS11B from activating other proteins through proteolysis, effectively reducing the proteolytic cascade TMPRSS11B is involved in. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
A serine protease inhibitor that covalently modifies the serine residue in the active site of TMPRSS11B, thereby inhibiting its protease activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
A reversible serine protease inhibitor that binds to the active site of TMPRSS11B, thereby preventing substrate access and inhibiting proteolytic activity. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
A competitive serine protease inhibitor that forms a reversible complex with TMPRSS11B, resulting in the inhibition of its protease activity. | ||||||
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
A reversible inhibitor that targets the active site of serine proteases such as TMPRSS11B, leading to the suppression of its enzymatic function. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
An irreversible cysteine protease inhibitor that, although not directly targeting serine proteases, could theoretically affect TMPRSS11B activity indirectly through the modulation of proteolytic pathways in which TMPRSS11B may be indirectly involved. | ||||||
Sivelestat | 127373-66-4 | sc-203938 | 1 mg | $105.00 | 2 | |
A neutrophil elastase inhibitor that may indirectly reduce TMPRSS11B activity by affecting protease-antiprotease balance, consequently impacting proteolytic processes TMPRSS11B is associated with. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
A broad-spectrum metalloprotease inhibitor that indirectly affects TMPRSS11B activity by altering the extracellular matrix remodeling, which may have downstream effects on TMPRSS11B's role in these processes. | ||||||