TMEM87B Activators
TMEM87B Activators encompass a diverse range of compounds that influence various signaling pathways and cellular processes, indirectly enhancing the activity of TMEM87B. Forskolin, by increasing cAMP levels, affects G protein-coupled receptor signaling, a pathway where TMEM87B could be indirectly involved. Similarly, PMA's activation of Protein Kinase C (PKC) suggests an enhancement of TMEM87B activity through PKC's role in multiple signaling pathways. Epidermal Growth Factor (EGF) and Insulin, through their respective receptor pathways, activate downstream signaling cascades like MAPK/ERK and PI3K/Akt, indirectly modulating cellular functions and enhancing TMEM87B's role. LY294002 and U0126 provide an example of how inhibiting a pathway can lead to compensatory mechanisms that might upregulate or enhance TMEM87B's activity. This concept is further extended with SB203580 and Rapamycinwhere the inhibition of these key pathways could lead to changes in cellular stress responses or growth processes, involving TMEM87B.
Further, Dexamethasone, through its modulation of various signaling pathways including NF-κB, can influence inflammatory responses, suggesting an indirect enhancement of TMEM87B activity in these contexts. Bafilomycin A1's impact on lysosomal function and autophagy could also modify cellular degradation pathways, indirectly involving TMEM87B. The role of NAD+ in metabolic pathways and DNA repair processes highlights how changes in cellular energy management and genomic stability could enhance TMEM87B activity. Ionomycin's elevation of intracellular calcium levels could affect calcium-dependent signaling pathways, providing another route for the indirect enhancement of TMEM87B activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an activator of adenylate cyclase, leads to an increase in cAMP levels. Elevated cAMP can enhance TMEM87B activity by influencing pathways that TMEM87B is indirectly linked to, such as G protein-coupled receptor signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activation of PKC can lead to downstream effects that enhance TMEM87B activity, considering PKC's role in various signaling pathways where TMEM87B might be a component. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, a calcium ionophore, increases intracellular calcium levels, which could affect calcium-dependent signaling pathways, potentially enhancing TMEM87B activity due to its potential involvement in calcium-mediated cellular processes. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which is crucial for many cellular processes. This activation can indirectly enhance TMEM87B activity by influencing metabolic pathways or other cellular functions where TMEM87B might play a role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it can modulate signaling pathways, potentially leading to a compensatory upregulation or enhanced activity of TMEM87B in certain contexts, as a response to altered PI3K/Akt pathway dynamics. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it could lead to changes in cellular stress responses, potentially enhancing TMEM87B activity if TMEM87B is involved in pathways related to cellular stress or repair mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central regulator of cell growth and metabolism. This inhibition can indirectly enhance TMEM87B activity by influencing cellular growth processes or autophagy, in which TMEM87B might be implicated. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can influence numerous signaling pathways, including NF-κB. This influence can indirectly enhance TMEM87B activity by affecting inflammatory responses or other cellular processes where TMEM87B is potentially involved. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is an inhibitor of the vacuolar-type H+-ATPase. This inhibition can affect lysosomal function and autophagy, potentially enhancing TMEM87B activity by altering cellular degradation and recycling pathways, where TMEM87B might be involved. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in redox reactions and sirtuin activation. Increasing NAD+ levels can enhance TMEM87B activity by influencing metabolic pathways and DNA repair processes, potentially involving TMEM87B in cellular energy management and genomic stability. | ||||||