TMEM87B Inhibitors

TMEM87B inhibitors, though not directly recognized, draw from a wide range of chemicals known to interfere with membrane protein functions. The calcium channel blocker, Verapamil, elucidates the importance of calcium regulation in influencing membrane protein behavior. Similarly, compounds such as Amiloride and Niflumic acid, which can target specific ion channels and transporters, shed light on the indirect methods to influence TMEM87B has any ion transport attributes.

Furthermore, the Na+/K+ pump inhibitor, Ouabain, and ATP-sensitive potassium channel blocker, Glibenclamide, emphasize how altering the ionic balance within the cell and on the membrane can offer ways to influence TMEM87B's function. This perspective is further supported by Tetraethylammonium (TEA), a known potassium channel blocker. Probenecid, an organic anion transporter inhibitor, and DIDS, a compound known to inhibit certain anion exchangers, demonstrate how targeting specific transporters can modulate TMEM87B is involved in similar anion transport processes. Furthermore, Genistein's function as a tyrosine kinase inhibitor illustrates how broader cellular signaling mechanisms can be targeted to influence membrane proteins.