TMEM248 Activators
TMEM248 activators are compounds that specifically modulate the activity of the transmembrane protein TMEM248 (Transmembrane Protein 248). TMEM248 is a protein that, as the name implies, spans the membrane of cells. Proteins in this category generally play crucial roles in various cellular processes, including signaling, cellular structure, and the transport of molecules across the cellular membrane. Though not much is widely published about the specific functions of TMEM248, proteins that are activators of transmembrane proteins usually affect the conformational state of these proteins, which in turn can modulate their activity. The activation of TMEM248 by these compounds could potentially alter the protein's normal function, which may have a range of cellular effects.
The chemistry behind TMEM248 activators is likely diverse, as different molecular structures can interact with the protein's active sites or allosteric sites to induce activity. These activators would have to be lipophilic enough to interact with the lipid-rich environment of the cell membrane, yet possess the necessary chemical features to bind specifically to TMEM248. This specificity is critical, as off-target effects could influence other transmembrane proteins and disrupt cellular function. The exact mechanism by which these activators modulate TMEM248 is an area of biochemical interest, as it contributes to our understanding of protein-protein interactions, intracellular signaling pathways, and membrane dynamics. Discovering and characterizing new TMEM248 activators involves a combination of approaches, including high-throughput screening, molecular docking, and various biochemical assays to confirm the interaction and activation of TMEM248.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various substrates, potentially enhancing the functional activity of TMEM248 through phosphorylation-dependent signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of substrates that may interact with or modulate the activity of TMEM248, thereby indirectly enhancing its function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent signaling pathways. These pathways could influence TMEM248 function by altering the membrane dynamics or interactions in which it participates. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a known inhibitor of various protein kinases. Inhibition of competitive signaling pathways by EGCG might enhance TMEM248 activity by preventing phosphorylation of molecules that negatively regulate TMEM248's functional pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can shift cellular signaling pathways by reducing PI3K activity. This may upregulate compensatory pathways that enhance TMEM248 activity or alter its function in a way that indirectly leads to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA may phosphorylate substrates that interact with or regulate TMEM248, thus indirectly enhancing the functional activity of TMEM248. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase involved in the MAPK/ERK pathway. Inhibition of this pathway may result in the upregulation of alternative signaling pathways that could enhance TMEM248's functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors and can initiate signaling cascades that may enhance the activity of TMEM248 through alterations in membrane dynamics or protein-protein interactions. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K8644 is an L-type calcium channel agonist that increases calcium influx. Elevated intracellular calcium may activate calcium-dependent pathways potentially enhancing the activity of TMEM248 by modulating its cellular context. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration. This increase can activate calcium-dependent signaling pathways, which may have a downstream effect on enhancing TMEM248 activity. | ||||||