TMEM179 Activators
TMEM179 activators encompass a diverse array of chemical compounds that exert their influence on cellular signaling pathways, thereby indirectly facilitating enhanced activity of the protein. Some activators work by increasing intracellular secondary messenger concentrations such as cAMP and cGMP. This is achieved through direct stimulation of enzymes like adenylyl cyclase or by inhibiting phosphodiesterases, thereby preventing the breakdown of these cyclic nucleotides. The elevated levels of cAMP and cGMP can potentially promote cellular environments conducive to TMEM179 activation, given that these messengers are integral to various signaling pathways. Other activators specifically modulate calcium ion concentrations within the cell. They do this by acting as ionophores or by directly stimulating calcium channels, leading to increased calcium influx. Since calcium signaling is a ubiquitous and versatile pathway, the resulting boost in intracellular calcium can indirectly enhance the activity of TMEM179 through calcium-dependent mechanisms.
Further to these, a subset of activators may influence post-translational modification of proteins, such as by activating kinases like PKC, which can phosphorylate several substrates that may include TMEM179, potentially leading to increased activity of the protein. Antioxidants that activate kinase pathways, such as those initiating AMPK, also contribute to creating a cellular state that can indirectly upregulate TMEM179 activity. Additionally, certain activators donate bioactive molecules like nitric oxide, which can engage in signaling leading to increased levels of cGMP, indirectly influencing TMEM179 activity through this route.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. This indirectly facilitates the activation of TMEM179 by sustaining elevated second messenger levels that may engage signaling pathways TMEM179 is involved in. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
An activator of protein kinase C (PKC) which can phosphorylate a variety of protein targets potentially including TMEM179, thereby possibly increasing its functional activity through post-translational modifications. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent signaling pathways that TMEM179 may be part of, which could in turn increase its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore which raises intracellular calcium levels and could thereby activate TMEM179 indirectly through calcium-dependent pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that directly raises intracellular cAMP levels, potentially enhancing the functional activity of TMEM179 by mimicking the effects of endogenous cAMP. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
An antioxidant that may activate AMP-activated protein kinase (AMPK), which can regulate various cellular processes. Activation of AMPK could lead to an environment that promotes the functional activity of TMEM179. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $74.00 $114.00 $374.00 | 18 | |
A nitric oxide donor that may lead to the activation of soluble guanylate cyclase and subsequent increase in cGMP levels, potentially creating conditions that favor TMEM179 activation through cGMP-dependent pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A selective phosphodiesterase 4 inhibitor that prevents cAMP breakdown, thus potentially increasing TMEM179 activity by maintaining elevated cAMP levels within cells. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
An L-type calcium channel agonist that increases intracellular calcium, which could activate TMEM179 indirectly via calcium-mediated signaling pathways. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
A cAMP analog that is resistant to degradation by phosphodiesterases. It increases cAMP levels, potentially leading to the activation of TMEM179 in a pathway that is cAMP dependent. | ||||||