TMEM175 Inhibitors

Chemical inhibitors of TMEM175 include a variety of compounds known to block potassium channels, directly impeding the ion transport function of this protein. Tetraethylammonium is a classic potassium channel blocker that can inhibit the movement of potassium ions through TMEM175, disrupting its physiological role in maintaining potassium ion homeostasis. Similarly, Quinine, a compound with a long history of medical use, also possesses the ability to obstruct the potassium conductance that is mediated by TMEM175, effectively diminishing its activity. Clofilium Tosylate and E-4031 are selective for certain potassium channels, and their interaction with TMEM175 can result in a direct inhibition of its potassium transport capabilities.

Furthermore, Dofetilide, Astemizole, and Sotalol are known for their ability to block specific potassium channels, which includes the conductance pathway facilitated by TMEM175. Amiodarone, with its broad spectrum of channel-blocking properties, has the capacity to interrupt the function of TMEM175 by obstructing its potassium channel activity. Glibenclamide, an ATP-sensitive potassium channel inhibitor, can suppress the ion transport function of TMEM175, as the protein's activity is dependent on the proper flow of potassium ions. Linopirdine, a potassium channel blocker, can diminish the activity of TMEM175 by preventing potassium ions from passing through its channel. Lastly, Riluzole, although primarily targeting sodium channels, can also modulate potassium channels, which includes the potential inhibition of TMEM175, thereby altering the protein's ability to conduct potassium ions. Each of these chemicals, through their interaction with potassium channels, can effectively inhibit the function of TMEM175 by blocking its ion transport activity, directly affecting the regulation of potassium homeostasis at a cellular level.