Molecular structure of Sotalol hydrochloride, CAS Number: 959-24-0
Sotalol hydrochloride (CAS 959-24-0)
See product citations (3)
Application:
Sotalol hydrochloride is a potent β adrenergic antagonist
CAS Number:
959-24-0
Purity:
≥99%
Molecular Weight:
308.82
Molecular Formula:
C12H20N2O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sotalol hydrochloride, a compound recognized for its class III antiarrhythmic properties, plays a pivotal role in the modulation of cardiac electrophysiology through its dual-action mechanism. It extends the duration of the action potential and refractory period of cardiac tissues, acting as a cornerstone in the study of cardiac arrhythmia mechanisms and the development of strategies for arrhythmia management. This extension is primarily achieved through its non-selective yet potent beta-adrenergic blocking activity, combined with its efficacy as a potassium channel blocker, a critical function denoted by an IC50 value of 43 µM.
Sotalol hydrochloride (CAS 959-24-0) References
- Stability of sotalol in two liquid formulations at two temperatures. | Nahata, MC. and Morosco, RS. 2003. Ann Pharmacother. 37: 506-9. PMID: 12659604
- Biopharmaceutical characterization of sotalol-containing oral immediate release drug products. | Alt, A., et al. 2004. Eur J Pharm Biopharm. 58: 145-50. PMID: 15207548
- Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations. | Sidhom, MB., et al. 2005. Int J Pharm Compd. 9: 402-6. PMID: 23925139
- Development of a gradient HPLC method for the simultaneous determination of sotalol and sorbate in oral liquid preparations using solid core stationary phase. | Matysova, L., et al. 2015. J Anal Methods Chem. 2015: 806736. PMID: 25878920
- Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function. | Broux, B., et al. 2016. Vet J. 208: 60-4. PMID: 26670333
- Atrial fibrillation management in a breeding stallion. | Heliczer, N., et al. 2017. J Vet Cardiol. 19: 299-307. PMID: 28336184
- Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4. | Polonini, H., et al. 2018. Int J Pharm Compd. 22: 516-526. PMID: 30384353
- Extemporaneous sotalol hydrochloride oral solutions for use in paediatric cardiology: formulation and stability study. | Klovrzová, S., et al. 2016. Eur J Hosp Pharm. 23: 33-37. PMID: 31156811
- Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs. | Liu, Y., et al. 2020. Drug Des Devel Ther. 14: 4263-4276. PMID: 33116414
- Effect of sotalol on human atrial action potential duration and refractoriness: cycle length dependency of class III activity. | Hayward, RP. and Taggart, P. 1986. Cardiovasc Res. 20: 100-7. PMID: 3708643
- Electrophysiological effects of sotalol--just another beta blocker? | Nathan, AW., et al. 1982. Br Heart J. 47: 515-20. PMID: 7082499
- Satalol-induced torsade de pointes. | Kontopoulos, A., et al. 1981. Postgrad Med J. 57: 321-3. PMID: 7301675
- Sotalol: from 'just another beta blocker' to 'the prototype of class III antidysrhythmic compound'. | Claudel, JP. and Touboul, P. 1995. Pacing Clin Electrophysiol. 18: 451-67. PMID: 7770366
- Sotalol: a new class III antiarrhythmic agent. | Zanetti, LA. 1993. Clin Pharm. 12: 883-91. PMID: 8137605
- Class III antiarrhythmic agents: the next wave. | Bauman, JL. 1997. Pharmacotherapy. 17: 76S-83S; discussion 89S-91S. PMID: 9085343
Inhibitor of:
β2-AR, AR, beta1-AR, Gβ 2, GPR175, KCNE1L, KCNF1, KCNG3, KCNH3, KCNH4, KIR2.2, MRAP2, Olfr1507, Olfr668, Olfr765, Olfr767, Olfr770, Olfr885, Olfr887, Olfr944, Olfr951, Olfr958, TMEM175, Trav9d-1, Troponin I-C, V1RC24, V1RC32, and V1rc5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sotalol hydrochloride, 10 mg | sc-203699 | 10 mg | $67.00 | |||
Sotalol hydrochloride, 50 mg | sc-203699A | 50 mg | $246.00 |