TMEM147 Activators
TMEM147 activators comprise a diverse set of chemical agents that can indirectly modulate the functionality of the protein TMEM147 based on its involvement in various cellular pathways. A significant subset of these activators operates through gene expression modulation mechanisms. Retinoic Acid, a renowned agent for its role in modulating gene expression, can indirectly stimulate TMEM147 if its expression or functionality falls under genes governed by retinoic acid. Similarly, epigenetic modulators like VPA and EPZ004777 introduce an intricate layer to TMEM147 modulation. Valproic Acid, for instance, affects gene expression patterns via histone acetylation, offering avenues for TMEM147 modulation if its activity or expression is governed by these epigenetic marks. On the other hand, EPZ004777, a DOT1L, lays its foundation on methylation-mediated gene regulation. TMEM147's interface with genes regulated by DOT1L-mediated methylation offers a platform for its modulation by EPZ004777.
Amplifying the scope, chemicals that modulate cellular energy dynamics and stress responses also present for indirect TMEM147 activation. AICAR, known for activating AMPK, has a profound influence on energy regulation within cells. Should TMEM147 play a role in AMPK-mediated pathways or be influenced by cellular stress parameters, AICAR stands as a prospective modulating agent. Another dimension includes cellular signaling modulators. Agents like DAPT, Rolipram, and SAG, influencing the Notch, cAMP, and Hedgehog signaling pathways respectively, present indirect modulation possibilities. The premise rests on TMEM147's functional overlap or interaction with these pathways. For instance, if TMEM147 is linked with any process governed by the Notch signaling cascade, DAPT's influence on this cascade can indirectly modulate TMEM147's functionality. As we continue to elucidate the detailed functional aspects of TMEM147 and its place within cellular signaling networks, these activators and their modes of action serve as valuable pointers toward understanding modulation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid modulates gene expression via retinoic acid receptors. If TMEM147's expression or function can be influenced by genes under the control of retinoic acid, then its activity can be indirectly enhanced by Retinoic Acid. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, central to cellular energy regulation. If TMEM147 is involved in AMPK-mediated pathways or processes influenced by cellular stress, AICAR can indirectly enhance its function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, as a PDE4 inhibitor, boosts cAMP levels. If TMEM147's activity is contingent on cAMP-driven pathways, its functionality can be indirectly modulated by Rolipram. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
By inhibiting PDEs, IBMX raises cAMP and cGMP levels, influencing cellular signaling pathways. If TMEM147's activity is linked with these cyclic nucleotide-governed pathways, its function can be indirectly influenced by IBMX. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
BIO's inhibition of GSK3β affects the Wnt/β-catenin pathway. If TMEM147's function intersects with processes modulated by β-catenin or associated molecules, its activity can be influenced by BIO. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT hinders the Notch signaling pathway by inhibiting γ-secretase. If TMEM147's function is connected with processes influenced by Notch signaling, its activity can be indirectly influenced by DAPT. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, as a phosphatase inhibitor, can impact cellular phosphorylation dynamics. If TMEM147's activity or expression is influenced by phosphorylation, this agent can indirectly modulate it. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
VPA impacts gene expression through histone acetylation modifications. If TMEM147's function or expression is susceptible to such epigenetic shifts, its activity can be indirectly modulated by VPA. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $206.00 $510.00 | 31 | |
SAG acts on the Hedgehog signaling pathway. If TMEM147 operates within this pathway or its influenced processes, its function can be indirectly modulated by SAG. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
As a DOT1L inhibitor, EPZ004777 affects methylation-regulated gene expression. If TMEM147's function intersects with genes influenced by DOT1L-mediated methylation, its activity can be influenced by this agent. | ||||||