The chemical class of TMEM132E activators encompasses compounds that, while not directly targeting TMEM132E, can influence its activity or expression through modulation of various cellular pathways and processes. This indirect activation approach is often necessary when direct activators are unknown or when the protein of interest plays a role in complex signaling networks. These activators typically work by either upregulating signaling pathways that lead to the increased expression or activity of TMEM132E or by altering cellular environments in a way that favors TMEM132E activity. For instance, Forskolin increases intracellular cAMP levels, which can have widespread effects on cellular signaling, potentially impacting TMEM132E. Similarly, PMA activates PKC, leading to cascades of cellular events that might influence TMEM132E function.
The effectiveness and specificity of these activators in modulating TMEM132E are subject to various factors, including cell type, the presence of other signaling molecules, and the overall physiological context. Thus, while these chemicals provide avenues for potentially influencing TMEM132E activity, their effects can be broad and sometimes unpredictable, necessitating careful experimental design and interpretation. In research settings, these activators are valuable tools for probing the function and regulation of TMEM132E, especially when direct activators are not available. They enable researchers to manipulate cellular pathways and observe resultant changes in TMEM132E activity or expression. This approach can yield insights into the biological roles of TMEM132E and its interactions with other cellular components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC), potentially influencing TMEM132E-related signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which might affect signaling pathways involving TMEM132E. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that can alter intracellular calcium levels, potentially affecting TMEM132E function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts Golgi apparatus function, potentially influencing the trafficking and function of TMEM132E. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, potentially affecting the maturation and function of TMEM132E. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor that can affect various signaling pathways, potentially influencing TMEM132E activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor, potentially affecting signaling pathways related to TMEM132E. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can affect cellular growth and signaling, potentially influencing TMEM132E function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum kinase inhibitor, potentially affecting kinases that regulate TMEM132E. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressant that affects calcineurin signaling, potentially influencing TMEM132E-related pathways. | ||||||