TMEM132A Inhibitors
Chemical inhibitors of TMEM132A can interact with the protein's activity through various mechanisms. Phorbol 12-myristate 13-acetate (PMA) can activate protein kinase C (PKC), which in turn can phosphorylate TMEM132A, possibly leading to changes in its conformation, internalization, or degradation. This results in a decrease in the protein's functional activity at the cell surface. Conversely, several PKC inhibitors, such as Bisindolylmaleimide I, Gö 6983, and Chelerythrine Chloride, can prevent the phosphorylation of TMEM132A by inhibiting PKC. This inhibition can prevent any activation of TMEM132A that is dependent on PKC-mediated phosphorylation. Similarly, Staurosporine, as a broad-spectrum kinase inhibitor, can impede various kinases involved in the phosphorylation of TMEM132A, thereby potentially altering its activity.
Other kinase inhibitors, like Genistein, which inhibits tyrosine kinases, can reduce the phosphorylation of TMEM132A, leading to a decrease in its activity. Phosphoinositide 3-kinases (PI3K) inhibitors such as Wortmannin and LY294002 can disrupt downstream signaling pathways that regulate TMEM132A, which can also result in inhibition of the protein's function. U73122, which inhibits phospholipase C (PLC), can reduce the levels of secondary messengers like diacylglycerol and inositol trisphosphate, thereby potentially impacting the activity of TMEM132A. Furthermore, the c-Jun N-terminal kinase (JNK) inhibitor SP600125 can decrease TMEM132A activity by preventing JNK-mediated phosphorylation. Lastly, inhibitors of mitogen-activated protein kinase kinase (MEK) and p38 MAP kinase, such as PD98059 and SB203580 respectively, can also decrease TMEM132A activity by interfering with their respective signaling pathways.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide range of target proteins. If TMEM132A is a substrate for PKC, phosphorylation by PKC after PMA activation could inhibit TMEM132A by changing its conformation or by promoting its internalization or degradation, resulting in reduced functional activity on the cell surface. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Although it is broad-spectrum, it can inhibit kinases that phosphorylate TMEM132A, potentially altering TMEM132A activity through prevention of phosphorylation-dependent activation or by promoting an inactive conformation of TMEM132A. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. If TMEM132A function is regulated by tyrosine phosphorylation, inhibition of related kinases by genistein would decrease the phosphorylation of TMEM132A, leading to a loss or reduction of its activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. If PKC activity modulates the function of TMEM132A, this inhibitor would prevent PKC-mediated phosphorylation events, which could inhibit the activity of TMEM132A if its function is dependent on such post-translational modifications. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). If TMEM132A activity is regulated by PI3K signaling, inhibiting PI3K with wortmannin would disrupt downstream signaling pathways, potentially leading to the inhibition of TMEM132A function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor. Similar to wortmannin, if TMEM132A is regulated by PI3K-dependent pathways, inhibition of PI3K activity by LY294002 could result in the inhibition of TMEM132A by altering its phosphorylation status or its interactions with other proteins that are regulated by PI3K signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a PKC inhibitor. It could inhibit TMEM132A if PKC is involved in the phosphorylation and regulation of TMEM132A, preventing activation or causing deactivation of TMEM132A. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a selective PKC inhibitor. By inhibiting PKC, it may prevent the phosphorylation of TMEM132A if such phosphorylation is necessary for TMEM132A's functional activity, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If JNK modulates TMEM132A activity possibly through a phosphorylation event, inhibition of JNK by SP600125 could lead to a decrease in TMEM132A activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK). If TMEM132A is part of a pathway involving MEK/ERK signaling, PD98059 would inhibit this pathway, potentially leading to a reduction in TMEM132A activity. | ||||||