TMEM130 Activators
TMEM130 activators represent a class of chemical compounds that are designed to modulate the function of the protein TMEM130, also known as CCDC47 (coiled-coil domain-containing protein 47). TMEM130 is an integral membrane protein that is ubiquitously expressed in various tissues within the body. The function of TMEM130 is not fully understood, but it is believed to play a role in cellular processes such as the regulation of calcium signaling and homeostasis, which is crucial for the proper functioning of cells. The modulation of TMEM130 by these activators can influence the protein's activity, leading to alterations in the intracellular processes that TMEM130 is associated with.
Activators targeting TMEM130 are chemical agents crafted to interact specifically with the protein in a way that enhances its natural activity. This class includes diverse molecules that may bind to different domains of the TMEM130 protein, potentially influencing its structure and function. The precise mechanism of action of these activators is an area of active research, and it often involves the modulation of the protein's ability to interact with other cellular components, affecting the downstream signaling pathways. The study of TMEM130 activators is an evolving field, where the understanding of the biochemical interactions and the consequences of modulating TMEM130 function is continually being refined. These insights contribute to the broader knowledge of cellular mechanisms and protein function within the complex network of biological systems.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate TMEM130, potentially enhancing its activity as a membrane protein involved in cellular processes such as signaling or ion transport. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. The rise in calcium levels can activate calcium-dependent kinases, which may then phosphorylate TMEM130, resulting in the enhancement of TMEM130's role in cellular signaling related to calcium homeostasis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to the phosphorylation of multiple substrates, including membrane proteins like TMEM130, thereby enhancing its activity in processes such as cell adhesion or signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that elevates intracellular cAMP by activating adenylyl cyclase. Increased cAMP activates PKA, which may target TMEM130 for phosphorylation, enhancing its activity and potentially modulating its role in cellular signaling pathways. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 is an L-type calcium channel agonist which increases calcium influx. Elevated intracellular calcium may enhance the activation of calcium-dependent proteins that interact with TMEM130, potentially increasing the functional activity of TMEM130 in calcium signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels. This increase can trigger the activation of calcium-dependent kinases that might phosphorylate TMEM130, thereby enhancing TMEM130's functional activity related to calcium-mediated signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor which can activate stress-activated protein kinases (SAPKs) like JNK. Activation of these kinases can result in the phosphorylation and potential enhancement of TMEM130's activity in stress-related signaling pathways. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a PKC inhibitor that, paradoxically, can lead to the activation of alternative pathways that might involve TMEM130. The inhibition of PKC can result in a compensatory enhancement of TMEM130's function in cellular processes where PKC is normally a negative regulator. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
Nitrendipine is an L-type calcium channel blocker that can lead to the activation of compensatory signaling pathways. These pathways might involve the phosphorylation and activation of TMEM130, enhancing its role in signaling processes that compensate for reduced calcium influx. | ||||||