TMEM125 Inhibitors
Chemical inhibitors of TMEM125 can modulate the protein's function by targeting various cellular signaling pathways and enzymes that indirectly influence its activity. SB-3CT, as a selective inhibitor of MMP-2, alters the extracellular matrix, which can affect the cellular microenvironment that interacts with TMEM125, potentially altering its role in cellular signaling. LY294002 and Wortmannin, both inhibitors of PI3K, disrupt the PI3K/AKT pathway, leading to changes in cellular processes such as survival and proliferation that can impact the functioning of TMEM125. Similarly, PD98059's inhibition of MEK in the MAPK/ERK pathway can have an effect on cell signaling, thereby indirectly influencing the TMEM125's activity, considering the broad role of MAPK/ERK in cell growth and differentiation.
Furthermore, U73122's action as a PLC inhibitor can perturb inositol phosphate and calcium signaling, which are significant for the regulation of TMEM125, given the importance of calcium in the activity regulation of transmembrane proteins. GF109203X and Go6983, which inhibit PKC, can alter signaling pathways and modify the phosphorylation status of proteins, thereby impacting TMEM125 functions. BAPTA-AM, by sequestering intracellular calcium, interferes with calcium-dependent signaling pathways, which could influence the operation of TMEM125. Inhibitors like ML-7, Y-27632, and KN-93, which target MLCK, ROCK, and CaMKII respectively, can affect cytoskeletal organization and calcium signaling, thus indirectly altering the function of TMEM125, as these pathways are crucial for maintaining cellular architecture and regulating transmembrane protein activities. Lastly, PP2, as an inhibitor of Src family tyrosine kinases, can modify cell proliferation and survival signaling pathways, which may influence TMEM125 activity due to the role of Src kinases in transmembrane protein regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $100.00 $380.00 | 15 | |
SB-3CT is a potent and selective inhibitor of matrix metalloproteinase 2 (MMP-2). Since MMP-2 can be involved in the degradation of extracellular matrix, its inhibition can affect the cellular microenvironment and signaling, which could potentially impact the function of TMEM125, as transmembrane proteins could interact with extracellular matrix components. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 disrupts the PI3K/AKT signaling pathway, which is crucial for various cellular processes including survival, proliferation, and growth. As TMEM125 is a transmembrane protein, its function could be influenced by alterations in these cellular processes controlled by the PI3K/AKT pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of this pathway could lead to altered cell signaling that may indirectly influence the functional activity of TMEM125, given that MAPK/ERK pathway affects numerous cellular functions including growth and differentiation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is a potent inhibitor of protein kinase C (PKC). PKC is involved in multiple signaling pathways and inhibiting it can lead to altered cell signaling that may indirectly inhibit TMEM125 functionality, since PKC can phosphorylate and regulate transmembrane proteins. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a broad-spectrum PKC inhibitor, similar to GF109203X, but it has a different inhibition profile across the PKC isozymes. By affecting PKC activity, Go6983 could alter signaling pathways that modulate the function of TMEM125, as PKC-mediated phosphorylation events can affect transmembrane protein activities. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a cell-permeant calcium chelator. By chelating intracellular calcium, it disrupts calcium-dependent signaling pathways. This disruption could influence the function of TMEM125 indirectly, as calcium plays a critical role in the functioning and regulation of transmembrane proteins. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). MLCK is involved in cytoskeletal dynamics by phosphorylating myosin light chains. Inhibiting MLCK could affect the cellular architecture and potentially influence the function of TMEM125 indirectly, as the cytoskeleton can interact with and regulate transmembrane proteins. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK). By inhibiting ROCK, it affects the organization of the actin cytoskeleton, which could indirectly inhibit TMEM125 function, as the interaction of the cytoskeleton with transmembrane proteins is critical for their proper functioning. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, similar to LY294002. It prevents the formation of PIP3 and disrupts the PI3K/AKT pathway, potentially affecting TMEM125 functionality indirectly because PI3K signaling influences various aspects of cellular processes that may engage transmembrane proteins. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Inhibition of CaMKII can disrupt calcium-dependent signaling which may indirectly affect the function of TMEM125, as CaMKII modulates various cellular processes including some that involve transmembrane proteins. | ||||||