TMEM106A Activators
Histamine activats its own set of receptors, orchestrates a different set of intracellular communications. Both of these pathways offer routes through which TMEM106A may be indirectly affected. Caffeine disrupts the quietude of adenosine receptors, leading to an upsurge in cAMP levels that subsequently activates protein kinase A (PKA) and could exert an influence on TMEM106A. Lithium Chloride, by inhibiting GSK-3β, disrupts the balance of protein phosphorylation, potentially shifting the operation of proteins that interact with TMEM106A. Retinoic Acid, with its capacity to modulate gene expression, could cause shifts in the protein landscape that includes TMEM106A regulators.
Forskolin and IBMX, through their actions on cAMP levels, create an environment ripe for PKA activation, which could cascade down to TMEM106A activity modulation. Similarly, Dibutyryl cAMP bypasses cellular receptors to directly stimulate PKA, again possibly affecting TMEM106A. The action of PMA as a direct activator of protein kinase C (PKC) might alter the phosphorylation state of proteins associated with TMEM106A, while Staurosporine's inhibition of PKC provides a counterbalance, potentially leading to changes in TMEM106A-related signaling pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Stimulates adrenergic receptors, which can trigger a cascade of G-protein-coupled receptor signaling that may influence TMEM106A. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Activates histamine receptors, potentially affecting intracellular signaling pathways that regulate TMEM106A. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Antagonizes adenosine receptors and increases cAMP levels, which could affect kinase signaling pathways associated with TMEM106A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, which might affect phosphorylation patterns of proteins interacting with TMEM106A. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Modulates gene expression, which could lead to changes in protein expression levels that are involved in regulating TMEM106A activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly activates adenylate cyclase, increasing cAMP and potentially affecting PKA activity related to TMEM106A. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, raises cAMP levels, and might enhance signaling pathways regulating TMEM106A. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Cell-permeable cAMP analog that can activate PKA and could influence pathways involving TMEM106A. | ||||||
PDGFR Tyrosine Kinase Inhibitor IV | 627518-40-5 | sc-205794 sc-205794A sc-205794B sc-205794C | 1 mg 5 mg 10 mg 50 mg | $27.00 $138.00 $257.00 $1127.00 | 2 | |
Another biological material that can activate tyrosine kinase receptors and influence TMEM106A-related pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Direct activator of PKC, which could modify the phosphorylation state of proteins associated with TMEM106A. | ||||||