TMC6 Inhibitors
Chemical inhibitors of TMC6 can interfere with its functionality through various mechanisms affecting ion transport and membrane integrity. Itraconazole inhibits the enzyme lanosterol 14α-demethylase, which is crucial for ergosterol synthesis. Since ergosterol is a vital component of certain cellular membranes, its depletion can alter the membrane composition and functionality where TMC6 operates. Amiloride, as a potassium-sparing diuretic, inhibits sodium channels, which can disturb the ionic balance across the cellular membrane and consequently impact TMC6's ion channel-related functions. Similarly, flufenamic acid and niflumic acid, both NSAIDs, inhibit chloride channels, which could affect TMC6's role in chloride ion transport across the cell membrane.
Bepridil, a calcium channel blocker, can inhibit voltage-gated calcium channels, potentially disrupting calcium-dependent signaling pathways that may influence TMC6 activity. In contrast, glybenclamide targets ATP-sensitive potassium channels, potentially altering the ion transport processes that TMC6 is associated with. Bumetanide, a loop diuretic, inhibits the Na-K-2Cl cotransporter, which could affect the sodium, potassium, and chloride ion balance, crucial for TMC6's function. Hexamethonium, by blocking nicotinic acetylcholine receptors, could indirectly affect the ion transport processes involving TMC6. Capsazepine, by antagonizing the TRPV1 receptor, can impact ion transport mechanisms where TMC6 is a factor. Clofilium tosylate, which blocks voltage-gated potassium channels, and mefloquine, which blocks gap junction communication, can influence cellular communication and ion transport processes associated with TMC6.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole is a triazole antifungal agent that inhibits the enzyme lanosterol 14α-demethylase. TMC6 is involved in the formation of pores in the cellular membrane and itraconazole, by disrupting membrane integrity through inhibition of ergosterol synthesis, could inhibit TMC6 by altering the cell membrane composition and function, which is essential for TMC6 activity. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride is a potassium-sparing diuretic that also functions as an inhibitor of certain ion channels. TMC6 has been associated with ion channel activity, and amiloride, by inhibiting sodium channels, could indirectly inhibit TMC6's ion channel-related functions by disrupting the ionic balance across the membrane where TMC6 is active. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $148.00 $459.00 | 11 | |
Capsazepine is a synthetic analog of capsaicin and a selective TRPV1 receptor antagonist. Given that TMC6 is implicated in ion transport and the creation of pores, capsazepine could inhibit TMC6 by antagonizing TRPV1, which may be indirectly involved in the regulation of ion transport mechanisms where TMC6 is a contributing factor. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker that can inhibit voltage-gated calcium channels. TMC6's functionality could be linked to calcium-dependent signaling pathways, and by blocking these channels, bepridil could inhibit these pathways, thus indirectly inhibiting TMC6's activity related to ion transport and membrane pore formation. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits certain chloride channels. TMC6 may interact with chloride channels in its functional role, and thus flufenamic acid could inhibit TMC6 by disrupting chloride ion transport, which may be necessary for TMC6 activity. | ||||||
Hexamethonium bromide | 55-97-0 | sc-205712 sc-205712A | 10 g 25 g | $46.00 $64.00 | ||
Hexamethonium is a nicotinic acetylcholine receptor antagonist that blocks the transmission of impulses in the autonomic ganglia. TMC6, which may contribute to ion transport across neuronal membranes, could be indirectly inhibited by hexamethonium's action on these receptors, subsequently affecting the ion transport processes TMC6 is involved in. | ||||||
Mefloquine Hydrochloride | 51773-92-3 | sc-211784 | 100 mg | $118.00 | 4 | |
Mefloquine is an antimalarial drug that can block gap junction communication. TMC6's role in cellular communication could be influenced by gap junctions, and mefloquine's inhibition of these channels could indirectly inhibit TMC6 by disrupting cellular communication pathways where TMC6 may play a part. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid is a member of the fenamate group of NSAIDs and acts as an inhibitor of certain chloride channels. Since TMC6 is associated with ion channel activity, niflumic acid could inhibit TMC6 by preventing chloride ion transport, which TMC6 may be involved in, thus affecting its functional role in the cell. | ||||||
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $437.00 $1040.00 | 1 | |
Clofilium tosylate is a potent blocker of the voltage-gated potassium channel. TMC6 is implicated in ion transport, and clofilium tosylate could inhibit TMC6 by inhibiting potassium channels, which may indirectly affect the ion transport processes that are associated with TMC6 activity. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glybenclamide is a sulfonylurea compound that inhibits ATP-sensitive potassium channels. TMC6 may be implicated in the regulation of potassium ion transport through its channel activity, and glybenclamide could inhibit TMC6 by disrupting the ion transport across the cell membrane that TMC6 is involved with. | ||||||