Tim10 Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin inhibits Hsp90, a chaperone protein involved in protein folding. As Tim10 requires proper folding for its function, the inhibition of Hsp90 disrupts its maturation, leading to decreased Tim10 activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits calcineurin, a phosphatase that activates NFAT. Tim10, regulated by NFAT, can be indirectly inhibited through the suppression of NFAT signaling, impairing its transcriptional control over Tim10 expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose hampers glycolysis, impacting energy production. Tim10, localized in the mitochondria, relies on energy availability. Reduced ATP levels due to glycolysis inhibition can indirectly suppress Tim10 function by compromising mitochondrial function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits complex I of the electron transport chain. Tim10's role in mitochondrial protein import requires an intact electron transport chain. Inhibiting complex I disrupts mitochondrial function, indirectly impairing Tim10 activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits vacuolar-type H+-ATPase, affecting lysosomal acidification. Tim10 interacts with mitochondrial proteins during import, and lysosomes play a role in degradation. Inhibition of lysosomal function indirectly influences Tim10-mediated processes. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP disrupts the proton gradient across the inner mitochondrial membrane. Tim10 participates in mitochondrial protein import, and membrane potential is essential. FCCP indirectly affects Tim10 by perturbing the electrochemical gradient. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-glycosylation during protein synthesis. Tim10 undergoes post-translational modifications, and inhibition of glycosylation disrupts proper maturation, indirectly leading to reduced Tim10 functionality. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates AMPK, an energy sensor. Tim10, being energy-dependent, can be indirectly influenced by Resveratrol through the AMPK pathway. Activation of AMPK alters cellular energy dynamics, indirectly modulating Tim10 function. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium Azide inhibits cytochrome c oxidase, impacting mitochondrial respiration. Tim10, associated with mitochondrial import, can be indirectly affected by compromised respiratory function, influencing its overall activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore, leading to intracellular calcium influx. Tim10 is sensitive to calcium levels. A23187's impact on calcium dynamics indirectly modulates Tim10 by influencing its calcium-dependent interactions and functions. | ||||||