THSD4 Activators
THSD4 Activators comprise a spectrum of chemical entities that indirectly facilitate the enhancement of THSD4's functional activity through a multitude of signaling mechanisms. Retinoic Acid serves to upregulate THSD4 expression by engaging retinoic acid receptors, which then bind to elements in the THSD4 gene's promoter region, leading to increased gene transcription. Forskolin and Dibutyryl cAMP elevate intracellular cAMP levels, which activate protein kinase A (PKA); the activated PKA potentially phosphorylates transcription factors, thereby boosting the expression and activity of THSD4. Epigallocatechin Gallate (EGCG) influences kinase pathways, altering the extracellular matrix interactions that could upregulate THSD4's activity. Lithium Chloride's inhibition of GSK-3β and the subsequent stabilization of β-catenin may also augment THSD4 expression through Wnt/β-catenin signaling pathways. The activation of protein kinase C (PKC) by Phorbol 12-myristate 13-acetate (PMA) and G protein-coupled receptor pathways by Sphingosine-1-phosphate both culminate in cellular responses that enhance the activity of THSD4.
The second paragraph delves deeper into the cellular impact of THSD4 Activators. Sodium Orthovanadate, by inhibiting tyrosine phosphatases, could amplify tyrosine phosphorylation-dependent pathways, leading to an indirect rise in THSD4 activity. Ionomycin facilitates an increase in intracellular calcium, which triggers calcium-dependent signaling pathways, potentially promoting THSD4 activity. Hydrogen Peroxide, a mediator in oxidative stress signaling, may indirectly activate THSD4 through the oxidative modification of associated signaling proteins. Nicotinamide Adenine Dinucleotide (NAD+), through its role in redox reactions and ADP-ribosylation, might affect pathways that lead to an upsurge in THSD4 activity. Lastly, Manganese (II) Chloride, as an enzymatic cofactor, could influence kinase and phosphatase pathways, further contributing to the enhancement of THSD4's activity. Collectively, these chemicals orchestrate a complex network of biochemical events that converge on the upregulation and activation of THSD4, each through a specific molecular interplay that underscores the multifaceted nature of cellular regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, interacts with retinoic acid receptors (RARs) which can then regulate gene expression. This regulation can enhance the expression of THSD4 by binding to retinoic acid response elements (RAREs) in the promoter region of the THSD4 gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels, which in turn activates PKA. PKA can phosphorylate transcription factors that may enhance the expression of THSD4 or proteins that interact with THSD4, thus enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that can modulate the activity of various kinases and has been shown to affect pathways that indirectly lead to the activation of proteins related to the extracellular matrix, which could include THSD4. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, leading to the stabilization of β-catenin, which can translocate to the nucleus and bind Wnt target gene promoters. This process might enhance the expression of THSD4, as it is potentially regulated by Wnt/β-catenin signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which is involved in various signaling pathways. PKC activation can lead to changes in protein interactions and functions, potentially enhancing the activity of THSD4. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that activates G protein-coupled receptors, potentially leading to downstream effects that enhance the activity of proteins like THSD4 within cellular signaling pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate is a general inhibitor of tyrosine phosphatases, which might enhance tyrosine phosphorylation-dependent signaling pathways, indirectly increasing the activity of THSD4. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways, similar to Forskolin, and may enhance THSD4 activity by influencing the phosphorylation status of proteins interacting with THSD4. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways, potentially leading to the enhancement of THSD4 activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide is involved in oxidative stress signaling and can modify signaling pathways through the oxidation of proteins, which may indirectly lead to the activation of THSD4. | ||||||