THAP5 Activators
THAP5 Activators belong to a specialized class of chemical compounds that interact with a cellular protein known as THAP5, or Thanatos-associated protein domain-containing apoptosis-associated protein 5. This protein is a part of the larger THAP domain protein family, characterized by a conserved zinc-dependent DNA-binding domain. THAP5 in particular has been identified as having a role in cellular processes related to the regulation of gene expression. The activators of this protein influence its activity within the cell, potentially affecting the way THAP5 interacts with DNA and other proteins. Such interactions are crucial for the precise control of genetic transcription and can impact a broad range of cellular functions.
The design and study of THAP5 Activators are grounded in the molecular understanding of the THAP5 protein's structure and functions. These activators are typically small molecules that can cross cellular membranes and reach intracellular targets such as THAP5. By binding to the protein, activators can induce a conformational change that either promotes or enhances the protein's natural activity. The specificity of these activators is of paramount importance, as off-target effects can lead to unintended interactions with other THAP domain proteins or unrelated cellular components. As a result, the development of THAP5 Activators involves rigorous biochemical and biophysical screening to ensure that they engage with THAP5 in a highly selective manner, thereby modulating the protein's activity in a controlled and precise fashion.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
As a potent activator of protein kinase C (PKC), PMA leads to the phosphorylation of various substrates, which could include proteins that interact with or regulate THAP5 activity, thus enhancing THAP5's function in the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. This, in turn, activates PKA which may phosphorylate substrates that modulate THAP5 activity or its interaction with other cellular components. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
By increasing intracellular calcium levels, ionomycin activates calcium-dependent signaling pathways that could lead to post-translational modifications of proteins that interact with THAP5, enhancing its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As an inhibitor of protein phosphatases PP1 and PP2A, okadaic acid results in increased phosphorylation within the cell, which could affect proteins that regulate THAP5, leading to enhanced THAP5 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases and might reduce competitive signaling, thereby potentially allowing pathways that enhance THAP5 activity to be more prominent. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 alters downstream signaling, which may include pathways that indirectly activate THAP5 by modulating interactions with other proteins or its localization in the cell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Similar to LY294002, wortmannin inhibits PI3K and could lead to the activation of alternative pathways that indirectly enhance THAP5 activity by affecting associated proteins. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
By inhibiting ATP synthase and altering mitochondrial function, oligomycin can change cellular energy status, potentially leading to a compensatory response that enhances THAP5 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor that alters chromatin structure and may lead to the exposure of promoter regions of genes that code for proteins interacting with THAP5, enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates signaling cascades which could include pathways that enhance THAP5 activity by promoting its stabilization or interaction with other cellular components. | ||||||