TGF beta 1 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin sodium functions as a potent modulator of TGF-beta 1 signaling, exhibiting unique binding affinities that disrupt protein-protein interactions. Its structure allows for the formation of stable complexes with growth factors, influencing downstream signaling cascades. The compound's ability to alter conformational dynamics enhances its reactivity, facilitating the regulation of cellular responses. Additionally, its interactions can lead to significant alterations in extracellular matrix composition, impacting cellular behavior. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
Inhibits TGF-β receptor type I (ALK5) kinase activity, preventing downstream signaling and reducing TGF-β-induced cellular responses. | ||||||
SIS3 hydrochloride | 521984-48-5 | sc-253565 | 5 mg | $334.00 | 2 | |
SIS3 hydrochloride acts as a selective inhibitor of TGF-beta 1 signaling, characterized by its ability to interfere with specific receptor interactions. This compound selectively alters the phosphorylation states of downstream signaling proteins, modulating their activity. Its unique structural features enable it to stabilize transient complexes, thereby influencing the kinetics of signal transduction. Furthermore, SIS3 hydrochloride can impact gene expression profiles by altering transcription factor activity, leading to distinct cellular outcomes. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $321.00 $1350.00 | 2 | |
Blocks ALK4, ALK5, and ALK7 receptors, preventing TGF-β-induced Smad2/3 phosphorylation and subsequent transcriptional responses. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
Selective inhibitor of TGF-β receptor I (ALK5), interfering with downstream signaling and reducing fibrosis and inflammation associated with TGF-β pathway activation. | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
Specific ALK5 inhibitor, preventing TGF-β-induced Smad2/3 phosphorylation and subsequent transcriptional responses. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
Alters TGF-β signaling by inhibiting ALK5 and ALK4, leading to reduced Smad2/3 phosphorylation and transcriptional responses. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
Selective inhibitor of ALK4, ALK5, and ALK7, interfering with TGF-β-induced Smad2/3 phosphorylation and gene expression changes. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
Blocks TGF-β receptor I (ALK5) activity, decreasing TGF-β signaling and downstream fibrotic responses in various cell types. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Inhibits both ALK5 and ALK4 receptors, reducing TGF-β-induced Smad2/3 phosphorylation and downstream effects. | ||||||